Functional neuroanatomy of the human premotor oculomotor brainstem nuclei: insights from postmortem and advanced in vivo imaging studies.
Functional neuroanatomy of the human premotor oculomotor brainstem nuclei: insights from postmortem and advanced in vivo imaging studies.
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人类运动前动眼神经脑干核的功能神经解剖学：来自尸检和先进体内成像研究的见解。
DOI：
10.1007/s00221-008-1342-8
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发表时间：
2008
影响因子：
2
通讯作者：
Deller,Thomas
中科院分区：
文献类型：
--
作者：
Rüb,Udo;Jen,JoannaC;Braak,Heiko;Deller,Thomas
近年来，灵长类眼神经系统的功能解剖学研究取得了很大进展，也加深了我们对人类眼神经系统结构、组织和功能的认识。在本综述中，我们第一次提供了一个概述的神经解剖学基础上的眼运动控制在人类揭示了一系列的死后研究，其中人类运动前眼脑干核被确定使用非常规的100 μm厚的连续组织切片染色的尼氏物质和脂褐素色素（尼氏色素染色，根据Braak）。数据从控制大脑和脊髓小脑共济失调3型，神经退行性疾病，严重损害oculabular功能的患者进行了讨论，并建议在尸检研究中的人运动前oculabular脑干核的识别。为了在活体患者中可视化运动前脑干核团，已经采用了现代脑成像技术，尽管成功有限。建立脑干核团的地形标志物可能是进一步阐明人类患者运动前眼脑干网络的功能神经解剖学的必要下一步。这将有助于放射科医生在活体患者中识别这些细胞核，并使临床医生能够监测影响眼神经系统的神经系统疾病的进展。
Considerable progress has been made recently in the field of the functional neuroanatomy of the primate oculomotor system, which has also improved our understanding of the structure, organization and function of the human oculomotor system. In the present review we provide for the first time an overview of the neuroanatomical basis of eye movement control in humans as revealed by a series of post-mortem studies in which the human premotor oculomotor brainstem nuclei were identified using unconventional 100 μm thick serial tissue sections stained for Nissl substance and lipofuscin pigment (Nissl-pigment stain according to Braak). Data from control brains and from patients suffering from spinocerebellar ataxia type 3, a neurodegenerative disease that severely impairs oculomotor function are discussed and recommendations for the identification of human premotor oculomotor brainstem nuclei in post-mortem studies are given. To visualize premotor brainstem nuclei in living patients, modern brain imaging techniques have been employed, albeit with limited success. Establishing topographic markers of brainstem nuclei may be a necessary next step to further elucidate the functional neuroanatomy of the premotor oculomotor brainstem network in human patients. This will help radiologists to identify these nuclei in living patients and will enable clinicians to monitor the progression of neurological disorders affecting the oculomotor system.