Molecules within molecules: Recognition through self-assembly
Molecules within molecules: Recognition through self-assembly
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DOI：
10.1073/pnas.042663699
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发表时间：
2002-04-16
影响因子：
11.1
通讯作者：
Rebek, J
中科院分区：
文献类型：
--
作者：
Hof, F;Rebek, J
完全围绕目标分子的合成分子受体可以通过使用非共价相互作用来创建。这些分子胶囊在大小、形状和化学互补性的基础上，选择性地隔离客体分子，使其免受主体溶剂和其他分子的影响。这种可逆的分离在宿主的范围内产生独特的行为；化学反应的催化和活性物种的稳定是最近证明的可能结果。试剂的间隔化也会对胶囊外发生的反应产生巨大影响，在相对简单的反应系统中产生非线性动力学。
Synthetic molecular receptors that completely surround their target molecules can be created through the use of noncovalent interactions. These molecular capsules selectively sequester guest molecules from the influence of bulk solvent and other molecules on the basis of size, shape, and chemical complementarity. This reversible isolation spawns unique behavior within the confines of the host; the catalysis of chemical reactions and the stabilization of reactive species are possible outcomes that have been recently demonstrated. Compartmentalization of reagents can also have a dramatic effect on reactions that take place outside of the capsule, producing nonlinear kinetics in relatively simple reaction systems.