Hedgehog signalling
Hedgehog signalling
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DOI：
10.1242/dev.120154
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发表时间：
2016-02-01
期刊：
影响因子：
4.6
通讯作者：
Ingham, Philip W.
中科院分区：
文献类型：
--
作者：
Lee, Raymond Teck Ho;Zhao, Zhonghua;Ingham, Philip W.
Hedgehog (Hh) 信号通路是后生动物发育的关键调节因子之一。 Hh 蛋白已被证明在许多发育过程中发挥作用，并已成为经典形态发生素的范例。 Hh 通路功能障碍是许多人类发育异常和疾病的基础，使其成为重要的治疗靶点。因此，对 Hh 信号传导的兴趣延伸到许多领域，从进化到癌症研究和再生医学。在此以及随附的海报中，我们概述了当前对 Hh 信号传导机制的理解，强调了物种之间的相似性和差异。
The Hedgehog (Hh) signalling pathway is one of the key regulators of metazoan development. Hh proteins have been shown to play roles in many developmental processes and have become paradigms for classical morphogens. Dysfunction of the Hh pathway underlies a number of human developmental abnormalities and diseases, making it an important therapeutic target. Interest in Hh signalling thus extends across many fields, from evo-devo to cancer research and regenerative medicine. Here, and in the accompanying poster, we provide an outline of the current understanding of Hh signalling mechanisms, highlighting the similarities and differences between species.