Sequence-regulated vinyl copolymers by metal-catalysed step-growth radical polymerization
Sequence-regulated vinyl copolymers by metal-catalysed step-growth radical polymerization
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DOI：
10.1038/ncomms1004
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发表时间：
2010-04-01
影响因子：
16.6
通讯作者：
Kamigaito, Masami
中科院分区：
文献类型：
--
作者：
Satoh, Kotaro;Ozawa, Satoshi;Kamigaito, Masami
蛋白质和核酸是序列调控的大分子，具有源自其完美测序的一级结构的各种性质。然而，合成聚合物，特别是乙烯基聚合物的序列调控尚未实现，并且是聚合物化学的最终目标之一。在这项研究中，我们报告了一种策略，以获得序列调控的乙烯基共聚物组成的苯乙烯，丙烯酸酯和氯乙烯单元使用金属催化的逐步增长自由基加聚反应的设计单体制备从常见的乙烯基单体建筑块。通过铜催化的逐步增长自由基聚合，设计了具有非共轭C = C和活性C-Cl键的单体，得到了具有完整的氯乙烯-苯乙烯-丙烯酸酯-丙烯酸酯序列的ABCC序列调控共聚物。这一策略可能为序列调控合成聚合物的研究开辟一条新的途径。
Proteins and nucleic acids are sequence-regulated macromolecules with various properties originating from their perfectly sequenced primary structures. However, the sequence regulation of synthetic polymers, particularly vinyl polymers, has not been achieved and is one of the ultimate goals in polymer chemistry. In this study, we report a strategy to obtain sequence-regulated vinyl copolymers consisting of styrene, acrylate and vinyl chloride units using metalcatalysed step-growth radical polyaddition of designed monomers prepared from common vinyl monomer building blocks. Unprecedented ABCC-sequence-regulated copolymers with perfect vinyl chloride-styrene-acrylate-acrylate sequences were obtained by copper-catalysed step-growth radical polymerization of designed monomers possessing unconjugated C = C and reactive C-Cl bonds. This strategy may open a new route in the study of sequence-regulated synthetic polymers.