MAST-CELLS AT SITES OF CARTILAGE EROSION IN THE RHEUMATOID JOINT
MAST-CELLS AT SITES OF CARTILAGE EROSION IN THE RHEUMATOID JOINT
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DOI：
10.1136/ard.43.1.76
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发表时间：
1984-01-01
影响因子：
27.4
通讯作者：
WOOLLEY, DE
中科院分区：
文献类型：
--
作者：
BROMLEY, M;FISHER, WD;WOOLLEY, DE
通过组织化学和超微结构技术检查[人类]类风湿性病变的软骨-血管翳连接，试图识别负责软骨降解的细胞。在3例类风湿性关节炎的软骨侵蚀部位发现肥大细胞。肥大细胞参与免疫反应，并产生血管活性和蛋白酶调节剂，组胺和肝素，以及它们自己的降解蛋白酶。肥大细胞与软骨侵蚀部位的密切联系表明它们可能在类风湿性关节炎关节破坏的病理生理学中起重要作用。
Cartilage-pannus junctions of the [human] rheumatoid lesion were examined by histochemical and ultrastructural techniques in an attempt to identify the cells responsible for cartilage degradation. Mast cells have been identified at sites of cartilage erosion in 3 specimens of rheumatoid joint. Mast cells participate in immunological reactions, and produce the vasoactive and proteinase-modulating agents, histamine and heparin, as well as their own degradative proteinases. The close association of mast cells with sites of cartilage erosion suggests they may play an important role in the pathophysiology of joint destruction in rheumatoid arthritis.