A Theoretical Paradigm for Evaluating Risk-Benefit of Status Epilepticus Treatment.
A Theoretical Paradigm for Evaluating Risk-Benefit of Status Epilepticus Treatment.
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DOI：
10.1097/wnp.0000000000000753
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发表时间：
2020-09
期刊：
影响因子：
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通讯作者：
Westover MB
中科院分区：
文献类型：
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作者：
Amorim E;McGraw CM;Westover MB
用麻醉药物积极治疗癫痫持续状态可以快速控制癫痫发作，但它可能导致严重的医疗并发症和更糟糕的结果。使用决策分析方法，这篇简明的综述为癫痫持续状态的积极和非积极治疗的个性化决策提供了一个框架。作者提出并回顾了指导癫痫持续状态治疗侵袭性风险-收益分析的最相关参数，并提出了基于现实世界的案例示例，以说明这些工具如何在床边使用，并指导未来难治性癫痫持续状态治疗的研究。
Aggressive treatment of status epilepticus with anesthetic drugs can provide rapid seizure control, but it might lead to serious medical complications and worse outcomes. Using a decision analysis approach, this concise review provides a framework for individualized decision making about aggressive and nonaggressive treatment in status epilepticus. The authors propose and review the most relevant parameters guiding the risk–benefit analysis of treatment aggressiveness in status epilepticus and present real-world–based case examples to illustrate how these tools could be used at the bedside and serve to guide future research in refractory status epilepticus treatment.