INBREEDING AND PREREPRODUCTIVE MORTALITY IN THE OLD ORDER AMISH .1. GENEALOGIC EPIDEMIOLOGY OF INBREEDING
INBREEDING AND PREREPRODUCTIVE MORTALITY IN THE OLD ORDER AMISH .1. GENEALOGIC EPIDEMIOLOGY OF INBREEDING
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DOI：
10.1093/oxfordjournals.aje.a114551
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发表时间：
1987-03-01
影响因子：
5
通讯作者：
MCKUSICK, VA
中科院分区：
文献类型：
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作者：
KHOURY, MJ;COHEN, BH;MCKUSICK, VA
研究人员使用宾夕法尼亚州阿米什人兰开斯特县的一个独特的家谱登记处对旧秩序阿米什人近亲繁殖的流行病学模式进行了调查，该登记处包含8,163对婚姻的信息，可以追溯到18世纪先驱移民的时代，跨越了10多代人。每对婚姻的亲属关系系数采用追踪多代系谱中共同祖先的路径法计算。由于广泛的家谱联系，平均亲属关系系数和近亲婚姻的比例随着时间的推移而显著增加，从1850年之前的0.004和37%分别增加到1950年之后的0.012和98%。与较高的亲属关系水平相关的人口因素包括结婚年龄小、夫妻双方的兄弟姐妹人数多、丈夫是农民以及婚姻发生在结婚季节（11月或12月）。随着时间的推移，阿米什人近亲繁殖水平的上升与世界上大多数地区近亲繁殖的下降形成了独特的对比。此外，由于与近亲繁殖水平高有关的一些人口因素可能与死亡率有关，因此在研究近亲繁殖对阿米什人死亡率的影响时必须考虑到这些因素。本研究采用流行病学的方法来评估随着时间的推移，在人口的近亲繁殖模式。
Epidemiologic patterns of inbreeding in the Old Order Amish were investigated using a unique genealogic registry of Lancaster County, Pennsylvania, Amish that contains information on 8,163 marriages, dating back to the time of the pioneer migrants in the 1700s and spanning more than 10 generations. The kinship coefficient for each marriage was computed using the path method of tracing common ancestors in the multigenerational pedigrees. Because of extensive genealogic connections, mean kinship coefficients and the proportion of related marriages have increased significantly over time, from 0.004 and 37%, respectively, for marriages before 1850 to 0.012 and 98%, respectively, for marriages after 1950. Demographic factors related to higher kinship levels include young age at marriage, large sibship size for both husband and wife, husband being a farmer, and marriages occurring in the marriage season (November or December). The rise in inbreeding levels in the Amish over time can be uniquely contrasted with the decline in inbreeding in most areas of the world. Furthermore, because some of the demographic factors related to high inbreeding levels may be associated with levels of mortality, such factors have to be taken into account when studying the effects of inbreeding on mortality in the Amish. This study uses an epidemiologic approach to the evaluation of inbreeding patterns in a population over time.