Developmental Motifs Reveal Complex Structure in Cell Lineages
Developmental Motifs Reveal Complex Structure in Cell Lineages
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DOI：
10.1002/cplx.20341
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发表时间：
2011-03-01
期刊：
影响因子：
2.3
通讯作者：
Wiles, Janet
中科院分区：
文献类型：
--
作者：
Geard, Nicholas;Bullock, Seth;Wiles, Janet
许多自然和技术系统是复杂的，其组织结构呈现出独特的模式，但无法进行简明的描述。分析这类系统的一种有效方法是根据重复的拓扑主题。在这里，我们扩展了Motif的概念，通过引入捕捉系统增长模式的发展Motif来表征复杂系统的动态行为。作为概念的证明，我们使用发育基序来分析线虫的发育细胞谱系，揭示了对其复杂结构的新视角。我们使用一系列计算模型来探索由于发育基因网络的动态以及作用于发育的空间和时间限制而产生的偏差是如何促成这个复杂的组织的。(C)2010 Wiley期刊，Inc.Complex 16：48-57,2011
Many natural and technological systems are complex, with organizational structures that exhibit characteristic patterns but defy concise description. One effective approach to analyzing such systems is in terms of repeated topological motifs. Here, we extend the motif concept to characterize the dynamic behavior of complex systems by introducing developmental motifs, which capture patterns of system growth. As a proof of concept, we use developmental motifs to analyze the developmental cell lineage of the nematode Caenorhabditis elegans, revealing a new perspective on its complex structure. We use a family of computational models to explore how biases arising from the dynamics of the developmental gene network, as well as spatial and temporal constraints acting on development, contribute to this complex organization. (C) 2010 Wiley Periodicals, Inc. Complexity 16: 48-57, 2011