Increased IL-37 concentrations in patients with arterial calcification
Increased IL-37 concentrations in patients with arterial calcification
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动脉钙化患者 IL-37 浓度升高
DOI：
10.1016/j.cca.2016.07.011
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发表时间：
2016-10-01
影响因子：
5
通讯作者：
Zeng, Qiutang
中科院分区：
文献类型：
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作者：
Yu, Kunwu;Min, Xiaohong;Zeng, Qiutang
背景：我们先前的研究表明，IL-37在动脉粥样硬化和动脉钙化中都起着关键作用。然而，动脉钙化患者的IL-37浓度是否发生显著变化尚未得到研究。方法：取自8例2型糖尿病患者和8例交通事故患者的胫前动脉壁标本。采用免疫组织化学方法检测钙化组织和正常组织中IL-37的表达。另外，对75例冠状动脉钙化(CAC)患者和50例无冠状动脉钙化(NCAC)患者的血浆IL-37浓度进行了检测。结果：钙化患者血浆IL-37浓度较高，而正常冠状动脉IL-37浓度较低。巨噬细胞和血管平滑肌细胞是IL-37的主要来源。CAC患者血浆IL-37浓度明显高于NCAC患者。相关分析显示，IL-37与年龄、空腹血糖、碱性磷酸酶、IL-6、TNE-α、C反应蛋白、Agatston评分呈正相关。二分类Logistic回归分析显示，空腹血糖和IL-37与CAC独立相关。结论：IL-37浓度升高与动脉钙化的发生有关。(C)2016爱思唯尔B.V.保留所有权利。
Background: Our previous study indicates that IL-37 plays a critical role in both atherosclerosis and arterial calcification. However, whether IL-37 concentrations are significantly changed in patients with arterial calcification has not yet been investigated.Methods: Anterior tibial arterial wall specimens were obtained from 8 patients with type 2 diabetes mellitus and 8 patients who experienced a traffic accident. IL-37 expression was measured by immunohistochemistry in the calcified and the normal samples. In addition, plasma IL-37 concentrations were measured in 75 patients with coronary artery calcification (CAC) and 50 patients without coronary artery calcification (NCAC).Results: High concentrations of IL-37 were detected in calcified samples, whereas low concentrations of IL-37 were detected in the normal arteries. Macrophages and vascular smooth muscle cells were the main source of IL-37. Plasma IL-37 concentrations were significantly increased in CAC patients compared with NCAC patients. A correlation analysis showed that IL-37 was positively correlated with age, fasting glucose, alkaline phosphatase, IL-6, TNE-alpha, C-reactive protein and Agatston scores. Binary logistic regression analyses demonstrated that fasting glucose and IL-37 were independently associated with the presence of CAC.Conclusions: Increased IL-37 concentrations are associated with the onset of arterial calcification. (C) 2016 Elsevier B.V. All rights reserved.