Blunted activation in right ventrolateral prefrontal cortex during motor response inhibition in schizophrenia
Blunted activation in right ventrolateral prefrontal cortex during motor response inhibition in schizophrenia
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DOI：
10.1016/j.schres.2007.07.033
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发表时间：
2007-12-01
影响因子：
4.5
通讯作者：
Mazzola-Pomietto, Pascale
中科院分区：
文献类型：
--
作者：
Kaladjian, Arthur;Jeanningros, Regine;Mazzola-Pomietto, Pascale
目的：先前的功能性磁共振成像（fMRI）研究报告了精神分裂症患者在执行运动抑制任务时的异常大脑激活。我们的目的是澄清精神分裂症的运动反应抑制相关的脑功能异常，通过使用事件相关的功能磁共振成像结合Go-NoGo任务，旨在控制非抑制性认知过程中涉及的任务性能。方法：我们研究了21名精神分裂症患者和21名健康受试者，在事件相关功能磁共振成像中，年龄，性别和Go-NoGo任务的性能准确性进行了组匹配。这个任务的设计是为了让Go和NoGo事件的概率相等。使用ANCOVA评估组间激活差异，将反应时间和IQ作为非关注协变量。结果如下：与健康受试者相比，精神分裂症患者在运动反应抑制期间仅在右腹外侧前额叶皮层（VLPFC）表现出显著的激活减少。与健康受试者相比，患者的大脑激活没有增加。结论：精神分裂症患者在右侧VLPFC表现出钝化的激活，该区域已知在运动反应抑制中起关键作用。进一步的研究应该确定VLPFC功能障碍对精神分裂症中观察到的冲动行为的贡献。(c)2007 Elsevier B. V.保留所有权利。
Objectives: Previous functional magnetic resonance imaging (fMRI) studies have reported abnormal brain activation in individuals with schizophrenia during performance of motor inhibition tasks. We aimed to clarify brain functional abnormalities related to motor response inhibition in schizophrenia by using event-related fMRI in combination with a Go-NoGo task designed to control for non-inhibitory cognitive processes involved in task performance. Method: We studied 21 schizophrenic patients and 21 healthy subjects, group-matched for age, sex, and performance accuracy on a Go-NoGo task during event-related fMRI. The task was designed so that Go and NoGo events were equally probable. Between-group activation differences were assessed using ANCOVAs with response time and IQ as covariates of non-interest. Results: Compared to healthy subjects, schizophrenic patients exhibited a significant decrease in activation during motor response inhibition in the right ventrolateral prefrontal cortex (VLPFC) only. There were no areas of increased brain activation in patients compared to healthy subjects. Conclusions: Schizophrenic patients demonstrate a blunted activation in the right VLPFC, a region known to play a critical role in motor response inhibition. Further research should ascertain the contribution of the VLPFC dysfunction to the impulsive behavior observed in schizophrenia. (c) 2007 Elsevier B.V. All rights reserved.