[Clinical studies of sixteen cases with pulmonary cryptococcosis mainly with respect to serum level of cryptococcal antigen].
[Clinical studies of sixteen cases with pulmonary cryptococcosis mainly with respect to serum level of cryptococcal antigen].
复制标题
16例肺隐球菌病以血清隐球菌抗原水平为主的临床研究
DOI：
10.11150/kansenshogakuzasshi1970.79.656
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
S. Kohno
中科院分区：
文献类型：
--
作者：
Y. Dohtsu;Y. Ishimatsu;H. Takatani;K. Minami;Keiji Inoue;N. Kohara;K. Yanagihara;Y. Higashiyama;Y. Miyazaki;Y. Hirakata;S. Kohno
对1998 ~ 2004年6年间16例肺隐球菌病患者血清隐球菌抗原滴度进行了临床研究。16例患者中12例血清隐球菌抗原阳性，3例经电视胸腔镜检查确诊，1例经支气管肺泡灌洗液隐球菌培养确诊。在这12例患者中，治疗后连续检测血清隐球菌抗原滴度。血清隐球菌抗原滴度在治疗后半个月至6个月下降。应用抗真菌药物治疗5 ~ 19个月，6例隐球菌抗原转阴。但4例重症肺炎患者隐球菌抗原滴度高且持续时间长。4例隐球菌抗原阴性的肺隐球菌病患者胸部CT检查，最大结节直径均≤ 15 mm。
Clinical studies of sixteen cases with pulmonary cryptococcosis, during the past six years between 1998 and 2004, were peformed mainly with respect to serum cryptococcal antigen titer. Serum cryptococcal antigen was positive in twelve of 16 cases, the other three cases were diagnosed by VATS, the other one by positive culture of cryptococcus in BALF. In these twelve cases, the serum cryptococcal antigen titer was continuously tested after treatment. The serum cryptococcal antigen titer decreased from half to 6 months after treatment. And the cryptococcal Ag changed to negative in six of the 12 cases by antifungal agents from 5 to 19 months. But four cases whose pneumonia was severe tended to have a high titer level of cryptococcal antigen and were positive for a long period. In the Chest CT of four pulmonary cryptococcosis case with negative cryptococcal antigen, all of the maximum nodule size was less than or equal to 15mm in diameter.