Microvascular Dysfunction and Cognitive Impairment.
Microvascular Dysfunction and Cognitive Impairment.
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DOI：
10.1007/s10571-015-0308-1
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发表时间：
2016-03
影响因子：
4
通讯作者：
Faraci FM
中科院分区：
文献类型：
--
作者：
De Silva TM;Faraci FM
近年来，血管危险因素对认知功能的影响引起了人们的广泛关注。脑血管系统对氧气、葡萄糖和其他营养物质的适当分配对于正确的认知能力至关重要。脑微血管系统是血管阻力的关键部位，也是小血管疾病的优先目标。虽然血管危险因素对微血管功能的有害影响是已知的，但这种功能障碍对认知缺陷的影响尚不清楚。在这篇综述中，我们总结了大脑微血管功能障碍的当前证据。我们强调特定血管危险因素（高血压、糖尿病和高同型半胱氨酸血症）对软脑膜和实质循环的影响。最后，我们讨论了微血管疾病和认知功能之间的潜在联系，强调了我们目前理解上的差距。
The impact of vascular risk factors on cognitive function has garnered much interest in recent years. The appropriate distribution of oxygen, glucose and other nutrients by the cerebral vasculature is critical for proper cognitive performance. The cerebral microvasculature is a key site of vascular resistance and a preferential target for small vessel disease. While deleterious effects of vascular risk factors on microvascular function are known, the contribution of this dysfunction to cognitive deficits is less clear. In this review, we summarize current evidence for microvascular dysfunction in brain. We highlight effects of select vascular risk factors (hypertension, diabetes and hyperhomocysteinemia) on the pial and parenchymal circulation. Lastly, we discuss potential links between microvascular disease and cognitive function, highlighting current gaps in our understanding.