NO control: nitric oxide directly regulates substrate delivery to NOS. Focus on "Nitric oxide can acutely modulate its biosynthesis through a negative feedback mechanism on L-arginine transport in cardiac myocytes".
NO control: nitric oxide directly regulates substrate delivery to NOS. Focus on "Nitric oxide can acutely modulate its biosynthesis through a negative feedback mechanism on L-arginine transport in cardiac myocytes".
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NO 控制：一氧化氮直接调节底物向 NOS 的输送。
DOI：
10.1152/ajpcell.00191.2010
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Gatto,Craig
中科院分区：
文献类型：
--
作者：
Gatto,Craig
虽然氨基酸精氨酸通常通过一氧化氮合酶（NOS）与NO产生相关，但它也参与尿素、肌酸、肌酸酐、胍丁胺、49种多胺的合成以及整体蛋白质合成。此外，它还影响激素释放（胰岛素，催乳素等）和嘧啶碱基的合成。因此，生理上51精氨酸参与蛋白质代谢废物的处置、肌肉代谢、血管52调节、免疫系统功能、神经传递、RNA合成和酶介导的53信号传导（4）。更重要的是，尽管所有细胞都需要精氨酸，但并非所有细胞都具有产生精氨酸的代谢能力，因此必须通过循环获得精氨酸。在必须外源性获得L-精氨酸的细胞中，似乎有适当的调节机制来调节通过阳离子氨基酸转运蛋白（CAT）摄取L-精氨酸的速率。令人惊讶的是，很少有报道将CAT作为可能的代谢调控位点。59鉴于信息有限，Zhou等人的报告，焦点60（28;见第C#页）中的当前文章特别重要。他们的论文描述了61个新鲜分离的大鼠心室心肌细胞的发现，内源性产生的一氧化氮（NO）62负调节L-精氨酸摄取（28）。在功能上，这种L-精氨酸转运似乎是通过阳离子氨基酸转运蛋白1和2（CAT-1和CAT-2A;分别为人基因64 SLC7A1和SLC7A2）介导的（25）。这一重要的观察结果扩展了Peluffo实验室先前的工作65，该工作在功能上鉴定CAT-1和CAT-2A对心肌中的L-精氨酸摄取的贡献相同（15，18）。这些观察结果确定了CAT在NO信号传导中的关键调节作用，从而有助于心肌生理学和病理生理学。69
Although the amino acid arginine is commonly associated with NO production via nitric 48 oxide synthase (NOS), it also participates in the synthesis of urea, creatine, creatinine, agmatine, 49 polyamines, as well as overall protein synthesis. Furthermore, it also influences hormone release 50 (insulin, prolactin, and others) and synthesis of pyrimidine bases. Thus, physiologically 51 arginine participates in disposal of protein metabolic waste, muscle metabolism, vascular 52 regulation, immune system function, neurotransmission, RNA synthesis, and hormone-mediated 53 signaling (4). More importantly, although all cells require arginine, not all cells possess the 54 metabolic capacity to produce it and thus must obtain arginine via the circulation. In cells that 55 must acquire L-arginine exogenously, it seems logical that there would be regulatory 56 mechanisms in place to moderate the rate of L-arginine uptake via cationic amino acid 57 transporters (CATs). Surprisingly, there are few reports that address CATs as possible metabolic 58 sites of regulation. 59In light of limited information, the report from Zhou et al., the current article in focus 60 (28; see p. C### in this issue) is particularly important. Their paper describes findings from 61 freshly isolated rat ventricular cardiomyocytes that endogenously produced nitric oxide (NO) 62 negatively regulates L-arginine uptake (28). Functionally, this L-arginine transport appears to be 63 mediated via the cationic amino acid transporters 1 and 2 (CAT-1 and CAT-2A; human genes 64 SLC7A1 and SLC7A2, respectively)(25). This important observation extends previous work 65 from the Peluffo laboratory functionally identifying CAT-1 and CAT-2A as equal contributors to 66 L-arginine uptake in cardiac muscle (15, 18). These observations identify a critical regulatory 67 role for CATs in NO signaling and thus contribute to cardiac muscle physiology and 68 pathophysiology. 69
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N-乙基马来酰亚胺区分人红细胞中的两个赖氨酸转运系统。
DOI：
--
发表时间：
1993
期刊：
Journal of Physiology
影响因子：
--
作者：
R. Devés;S. Angelo;P. Chávez
通讯作者：
P. Chávez
影响因子：
56.9
作者：
Xu, L;Eu, JP;Stamler, JS
通讯作者：
Stamler, JS
DOI：
10.1073/pnas.0300464101
发表时间：
2004-02-24
影响因子：
11.1
作者：
Ravi, K;Brennan, LA;Black, SM
通讯作者：
Black, SM
一氧化氮合酶抑制剂通过人红细胞中的阳离子氨基酸载体的转运。
影响因子：
5.8
作者：
M. I. Forray;S. Angelo;C. Boyd;R. Devés
通讯作者：
R. Devés
DOI：
10.1073/pnas.84.24.9265
发表时间：
1987-12-01
影响因子：
11.1
作者：
IGNARRO, LJ;BUGA, GM;CHAUDHURI, G
通讯作者：
CHAUDHURI, G