Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It.
Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It.
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DOI：
10.1021/acsinfecdis.5b00097
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发表时间：
2015
影响因子：
5.3
通讯作者：
Gnanakaran S
中科院分区：
文献类型：
--
作者：
Zgurskaya HI;Löpez CA;Gnanakaran S
革兰氏阴性菌对许多抗生素具有内在耐药性。已获得多药耐药性并导致无法有效治疗的感染的物种对公共卫生构成严重威胁。这一问题已得到广泛承认，并在基本和应用两个层面得到解决。本文综述了革兰氏阴性病原体低渗透屏障的分子基础，这是发现和开发有效对抗此类病原体的抗生素的主要障碍。还讨论了打破这一障碍和实现对困难的革兰氏阴性菌的有效活动的知识和具体策略的差距。
Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have acquired multidrug resistance and cause infections that are effectively untreatable present a serious threat to public health. The problem is broadly recognized and tackled at both the fundamental and applied levels. This paper summarizes current advances in understanding the molecular bases of the low permeability barrier of Gram-negative pathogens, which is the major obstacle in discovery and development of antibiotics effective against such pathogens. Gaps in knowledge and specific strategies to break this barrier and to achieve potent activities against difficult Gram-negative bacteria are also discussed.