Prognostic factors of tracheobronchial mucoepidermoid carcinoma - 15 years experience
Prognostic factors of tracheobronchial mucoepidermoid carcinoma - 15 years experience
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DOI：
10.1111/j.1440-1843.2007.01207.x
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发表时间：
2008-03-01
期刊：
影响因子：
6.9
通讯作者：
Liu, Shih-Feng
中科院分区：
文献类型：
--
作者：
Chin, Chien-Hung;Huang, Chao-Cheng;Liu, Shih-Feng
背景与目的：气管支气管树状粘液表皮样癌是一种罕见的肿瘤，临床上表现为不同程度的侵袭性和恶性。患者的预后与肿瘤的组织学特征和临床行为之间的关系尚不确定。本研究的目的是确定临床病理特征和分析患者的结果与这种类型的癌症。方法：回顾性分析我院1991 ~ 2006年诊断为肺黏液表皮样癌的病例资料。结果：本研究纳入15例患者。组织学分级越高的肿瘤鳞状细胞比例越高（P = 0.019）；有淋巴结转移的患者肿瘤中鳞状细胞的比例高于无淋巴结转移的患者（P = 0.015）。早期肿瘤（IA期、IB期、IIB期）患者的预后（10年生存率= 87.5%）优于晚期肿瘤（IIIB期、IV期）患者（1年生存率= 28.6%；2年生存率= 0%,P = 0.001）。低级别肿瘤（1级和2级）患者的预后（1年生存率= 80%，5年生存率= 57.1%）优于高级别肿瘤（3级）患者（1年生存率= 20%,P = 0.035）。在Cox比例风险分析中，肿瘤分期是生存的重要独立预测因子。结论：鳞状细胞在肿瘤组织学上的比例可能是判断肿瘤恶性程度的一个指标。肿瘤、淋巴结、转移分期是气管支气管黏液表皮样癌患者预后的重要决定因素。
Background and objectives: Mucoepidermoid carcinoma of the tracheobronchial tree is a rare tumour which displays a variable degree of clinical aggressiveness and malignancy. The relationship between the patient's prognosis and the tumour's histological features and clinical behaviour is uncertain. The aim of this study was to identify the clinicopathological features and analyse the outcomes of patients with this type of cancer.Methods: A retrospective analysis of the medical records of patients diagnosed with mucoepidermoid carcinoma of the lung between 1991 and 2006 was conducted.Results: The study comprised 15 patients. Higher histological grade tumours had a higher proportion of squamoid cells (P = 0.019); the tumours of patients with lymph node metastases also had a higher proportion of squamoid cells than did the tumours of patients without lymph node metastases (P = 0.015). Patients with early stage tumours (stage IA, IB, IIB) had better outcomes (10-year survival rate = 87.5%), than did patients with late-stage tumours (stage IIIB, IV) (1-year survival rate = 28.6%; 2-year survival rate = 0%, P = 0.001). Patients with lower-grade tumours (grade 1 and grade 2) had better outcomes (1-year survival rate = 80%; 5-year survival rate = 57.1%) than did patients with higher-grade tumours (grade 3) (1-year survival rate = 20%, P = 0.035). Tumour staging was a significant independent predictor of survival on Cox proportional hazards analysis.Conclusions: The proportion of squamoid cells on tumour histology may be an indicator of the level of tumour malignancy. Tumour, node, metastasis staging is a significant determinant of prognosis in patients with tracheobronchial mucoepidermoid carcinoma.