SURVIVAL AND DEMENTIA - A 7-YEAR FOLLOW-UP OF AN ITALIAN ELDERLY POPULATION
SURVIVAL AND DEMENTIA - A 7-YEAR FOLLOW-UP OF AN ITALIAN ELDERLY POPULATION
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DOI：
10.1016/0167-4943(94)00612-b
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发表时间：
1995-01-01
影响因子：
4
通讯作者：
GIANNANDREA, E
中科院分区：
文献类型：
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作者：
BONAIUTO, S;MELE, M;GIANNANDREA, E
本研究的目的是调查老年意大利人口痴呆症和死亡率之间的关联。痴呆症受试者是由先前的阿尔茨海默病（AD）和特定痴呆症的患病率研究确定的。研究样本包括所有60岁及以上的阿皮尼亚诺居民（778名受试者），并进行了为期约7年的随访。从Appignano登记处获得定期死亡日期记录。我们发现先前诊断为痴呆综合征的受试者的死亡率（1年时为12.5%，约7年时为81.3%）明显高于非痴呆患者（1年时为3.0%，约7年时为21.5%）。在整个随访期间死亡的痴呆受试者中，男性高于女性（100% vs. 66.7%），并且随着年龄的增加而显著增加（60-69岁年龄组为50.0%，70-79岁年龄组为76.5%，80岁以上年龄组为86.2%）。多梗死性痴呆（MID）和混合性痴呆（MD）患者的死亡率往往略高于受AD影响的患者。我们的研究结果与先前基于人群的痴呆患者生存研究中报道的结果一致。
The objective of this study was to investigate the association between dementia and mortality in an elderly Italian population. Demented subjects were identified by a previous prevalence study of Alzheimer's disease (AD) and specific dementing disorders. The study sample included all inhabitants of Appignano aged 60 and over (778 subjects), and was followed-up over a period of about 7 years. Periodic records of dates of death were obtained from the Registry Office of Appignano. We found considerably higher mortality ratios for subjects previously diagnosed as having dementia syndrome (12.5% at 1 year and 81.3% at about 7 years) than for those who were non-demented (3.0% at 1 year and 21.5% at about 7 years). In the group of demented subjects who died during the whole period of follow-up was higher among men than women (100% vs. 66.7%) and increased considerably with increasing age (50.0% for age class 60-69, 76.5% for age class 70-79, and 86.2% for age class 80+). Mortality of subjects with multi-infarct dementia (MID) and mixed dementia (MD) tended to be slightly higher than in subjects affected by AD. Our results are consistent with those reported in previous population-based studies on survival of dementia patients.