EXPRESSION OF THE ADENOVIRUS E1A ONCOGENE DURING CELL-TRANSFORMATION IS SUFFICIENT TO INDUCE SUSCEPTIBILITY TO LYSIS BY HOST INFLAMMATORY CELLS
EXPRESSION OF THE ADENOVIRUS E1A ONCOGENE DURING CELL-TRANSFORMATION IS SUFFICIENT TO INDUCE SUSCEPTIBILITY TO LYSIS BY HOST INFLAMMATORY CELLS
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DOI：
10.1073/pnas.83.18.6965
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发表时间：
1986-09-01
影响因子：
11.1
通讯作者：
PILDER, SH
中科院分区：
文献类型：
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作者：
COOK, JL;WALKER, TA;PILDER, SH
非致癌人腺病毒转化的哺乳动物细胞对宿主单核炎性细胞的破坏表现出高度敏感性。我们已经分析了病毒基因调节转化细胞对自然杀伤细胞和活化的巨噬细胞裂解的易感性。腺病毒E1转化基因区重叠片段转化的靶细胞系的比较显示，单个癌基因E1A的单独表达足以在没有可检测的病毒移植抗原的转化细胞表面表达的情况下引起细胞溶解易感性增加，并且与杀伤细胞和靶细胞之间的组织相容性抗原身份无关。这些结果表明，癌基因的功能，不与以前公认的细胞表面靶结构的表达可能会积极诱导肿瘤细胞消除的主机免疫监视系统的组件。
Mammalian cells transformed by nononcogenic human adenoviruses exhibit high susceptibility to destruction by host mononuclear inflammatory cells. We have analyzed the viral gene regulation of the susceptibility of transformed cells to lysis by natural killer cells and activated macrophages. Comparisons of target cell lines transformed by overlapping segments of the adenovirus E1-transforming gene region revealed that isolated expression of a single oncogene, E1A, was sufficient to cause increased cytolytic susceptibility in the absence of detectable transformed cell-surface expression of viral transplantation antigens and irrespective of histocompatibility antigen identity between killer cells and target cells. These results suggest that oncogene functions that are not linked to the expression of previously recognized cell-surface target structures may actively induce neoplastic cell elimination by components of the host immune surveillance system.