Bcl-2 family proteins: master regulators of cell survival
Bcl-2 family proteins: master regulators of cell survival
复制标题
DOI：
10.1515/bmc-2016-0015
复制
发表时间：
2016-08-01
影响因子：
--
通讯作者：
Racay, Peter
中科院分区：
文献类型：
--
作者：
Hatok, Jozef;Racay, Peter
Bcl-2家族蛋白的最突出功能是调节细胞凋亡的内在（线粒体）途径的起始。然而，最近的研究表明，除了调节线粒体凋亡外，Bcl-2家族的蛋白质在调节其他细胞途径中发挥重要作用，对细胞存活具有强烈影响，如自噬，内质网（ER）应激反应，细胞内钙动力学，细胞周期进程，线粒体动力学和能量代谢。本文综述了Bcl-2家族蛋白与细胞存活相关的功能。
The most prominent function of proteins of the Bcl-2 family is regulation of the initiation of intrinsic (mitochondrial) pathways of apoptosis. However, recent research has revealed that in addition to regulation of mitochondrial apoptosis, proteins of the Bcl-2 family play important roles in regulating other cellular pathways with a strong impact on cell survival like autophagy, endoplasmic reticulum (ER) stress response, intracellular calcium dynamics, cell cycle progression, mitochondrial dynamics and energy metabolism. This review summarizes the recent knowledge about functions of Bcl-2 family proteins that are related to cell survival.