Boolean control of aptamer binding states
Boolean control of aptamer binding states
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DOI：
10.1021/ja051362f
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发表时间：
2005-08-17
影响因子：
15
通讯作者：
Stojanovic, MN
中科院分区：
文献类型：
--
作者：
Kolpashchikov, DM;Stojanovic, MN
执行布尔计算的分子可以分析一系列输入，并根据输入的存在或不存在以及它们编码的特定公式来决定产生或不产生输出。我们现在报告说，由脱氧核酶为基础的逻辑门进行的分子计算可以用来控制适体的功能状态，根据这种计算的结果打开或关闭它们。
Molecules that perform Boolean calculations can analyze a series of inputs and make a decision to produce or not to produce an output, based on the presence or absence of inputs and a particular formula they encode. We now report that molecular computation performed by deoxyribozyme-based logic gates can be used to control the functional state of aptamers, switching them on or off based on the outcome of such computation.