Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers.
Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers.
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DOI：
10.1038/tp.2016.191
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发表时间：
2016-11-01
影响因子：
6.8
通讯作者：
Clarke G
中科院分区：
文献类型：
--
作者：
Allen AP;Hutch W;Borre YE;Kennedy PJ;Temko A;Boylan G;Murphy E;Cryan JF;Dinan TG;Clarke G
心理生物学的新兴概念--具有潜在心理健康益处的活微生物--代表了一种管理与压力相关的疾病的新方法。大多数研究都集中在动物模型上。最近的临床前研究已经确定B.long um 1714菌株是一种假定的心理生物，会对应激相关行为、生理和认知表现产生影响。目前尚不清楚这种临床前效应是否能转化为健康的人类志愿者。我们测试了心理生物消费是否会影响压力反应、认知和大脑活动模式。在参与者内部设计中，健康志愿者(N=22)完成了认知评估、静息脑电图，并在基线、服用安慰剂和服用心理生物后接受了社会评估的冷加压测试。对社会评估的冷加压试验的反应，皮质醇产量和主观焦虑的增加是减弱的。此外，每日报道的压力通过心理生物消费而减少。我们还观察到海马体依赖的视觉空间记忆表现的细微改善，以及在精神生物消费后额叶中线脑电活动能力的增强。这些微妙但明显的好处与临床前筛查平台的预期影响是一致的。我们的结果表明，摄入B.long um 1714与减少压力和改善记忆力有关。有必要进行进一步的研究，以评估这种假定的心理生物在相关压力相关条件下的益处，并揭示这种影响的潜在机制。
The emerging concept of psychobiotics—live microorganisms with a potential mental health benefit—represents a novel approach for the management of stress-related conditions. The majority of studies have focused on animal models. Recent preclinical studies have identified the B. longum 1714 strain as a putative psychobiotic with an impact on stress-related behaviors, physiology and cognitive performance. Whether such preclinical effects could be translated to healthy human volunteers remains unknown. We tested whether psychobiotic consumption could affect the stress response, cognition and brain activity patterns. In a within-participants design, healthy volunteers (N=22) completed cognitive assessments, resting electroencephalography and were exposed to a socially evaluated cold pressor test at baseline, post-placebo and post-psychobiotic. Increases in cortisol output and subjective anxiety in response to the socially evaluated cold pressor test were attenuated. Furthermore, daily reported stress was reduced by psychobiotic consumption. We also observed subtle improvements in hippocampus-dependent visuospatial memory performance, as well as enhanced frontal midline electroencephalographic mobility following psychobiotic consumption. These subtle but clear benefits are in line with the predicted impact from preclinical screening platforms. Our results indicate that consumption of B. longum 1714 is associated with reduced stress and improved memory. Further studies are warranted to evaluate the benefits of this putative psychobiotic in relevant stress-related conditions and to unravel the mechanisms underlying such effects.