The antiproliferative effect of bovine lactoferrin on canine mammary gland tumor cells.
The antiproliferative effect of bovine lactoferrin on canine mammary gland tumor cells.
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DOI：
10.1292/jvms.70.443
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发表时间：
2008-05
期刊：
影响因子：
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通讯作者：
Yuichi Yamada;R. Sato;Saori Kobayashi;C. Hankanga;O. Inanami;M. Kuwabara;Yutaka Momota;N. Tomizawa;J. Yasuda
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文献类型：
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作者：
Yuichi Yamada;R. Sato;Saori Kobayashi;C. Hankanga;O. Inanami;M. Kuwabara;Yutaka Momota;N. Tomizawa;J. Yasuda
乳铁蛋白具有多种生物活性，包括在一些人和动物肿瘤细胞中具有抗肿瘤活性。基于这些效应，已经在人类医学中进行了临床试验。然而，乳铁蛋白在兽药中的抗肿瘤作用尚不清楚。在这项体外研究中，我们证明了犬乳腺肿瘤细胞（CIPp和CHMp）与牛乳铁蛋白共孵育诱导肿瘤细胞生长停滞。这种生长停滞与G1停滞的诱导有关。此外，这种作用在肿瘤细胞中比在正常细胞中更强。这些结果表明，牛乳铁蛋白在犬乳腺肿瘤中具有抗肿瘤活性，具有应用于患瘤犬的潜力。
Lactoferrin has several biological activities, including antitumor activities in some human and animal tumor cells. Clinical trials have been carried out in human medicine based on these effects. However, the antitumor effects of lactoferrin in veterinary medicine remain unknown. In this in vitro study, we demonstrated that co-incubation of canine mammary gland tumor cells (CIPp and CHMp) and bovine lactoferrin induced growth arrest of tumor cells. This growth arrest was associated with induction of G1 arrest. Furthermore, this effect was stronger in tumor cells than in normal cells. These findings demonstrate that bovine lactoferrin has anti-tumor activity in canine mammary tumors and has the potential for use in tumor-bearing dogs.