Aujeszky's disease (pseudorabies) virus: the virus and molecular pathogenesis - State of the art, June 1999
Aujeszky's disease (pseudorabies) virus: the virus and molecular pathogenesis - State of the art, June 1999
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DOI：
10.1051/vetres:2000059
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发表时间：
2000-01-01
影响因子：
4.4
通讯作者：
Mettenleiter, TC
中科院分区：
文献类型：
--
作者：
Mettenleiter, TC
近年来，在了解伪狂犬病病毒(PRV)蛋白质功能的分子基础方面取得了相当大的进展。伪狂犬病病毒是Aujeszky病(AD)的病原体。主要内容包括病毒包膜糖蛋白和细胞病毒受体的鉴定和功能特征，涉及神经毒力和神经致病的病毒蛋白的阐明，存在于成功减毒活疫苗中并导致成功的减毒活疫苗的减毒突变的检测和特征，以及PRV DNA基因组序列的接近完成。这篇综述是在为1993年在匈牙利布达佩斯举行的AD研讨会准备的一篇文章之后进行的，将简要总结这些最新发展，并更新读者对PRV研究的最新状态。
Considerable progress has been made during the last years in understanding the molecular basis of protein function in pseudorabies virus (PrV), the causative agent of Aujeszky's disease (AD). Major topics have been the identification and functional characterisation of viral envelope glycoproteins and cellular virus receptors, elucidation of viral proteins involved in neurovirulence and neuropathogenesis, detection and characterisation of attenuating mutations present in and leading to successful attenuated live vaccines, and the near completion of the genomic sequence of PrV DNA. This review, which follows an article prepared for the 1993 AD symposium in Budapest, Hungary, will briefly summarise those recent developments and update the reader on the current state of the art in PrV research.