Histopathological differences in patients with biopsy-proven non-alcoholic fatty liver disease with and without type 2 diabetes
Histopathological differences in patients with biopsy-proven non-alcoholic fatty liver disease with and without type 2 diabetes
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DOI：
10.1016/j.endinu.2017.12.011
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发表时间：
2018-06-01
影响因子：
1.9
通讯作者：
de Luis Roman, Daniel Antonio
中科院分区：
文献类型：
--
作者：
Aller de la Fuente, Rocio;Mora Cuadrado, Natalia;de Luis Roman, Daniel Antonio
背景和目标：在发达国家，非酒精性脂肪性肝病（NAFLD）的患病率在一般人群中为30%，在2型糖尿病（T2 DM）患者中为50%。本研究的目的是比较在患有和不患有T2DM.Patients和方法的受试者中通过肝活检和使用非侵入性指数NAFLD纤维化评分（NFS）评估的NAFLD的严重程度：研究样本包括217例活检证实的NAFLD患者。结果：T2 DM患者（n = 36; 16.5%）HOMA-IR值较高（6.3 +/-3.6 vs. 3.3 +/- 2.4; P < 0.05），但T2 DM患者的HOMA-IR值较T2 DM患者高（6.3 +/- 3.6 vs. 3.3 +/- 2.4; P < 0.05），且T2 DM患者的HOMA-IR值较T2 DM患者高（P < 0.05），但T2 DM患者的HOMA-IR值较T2 DM患者高（P < 0.05）。
Background and aims: Prevalence of non-alcoholic fatty liver disease (NAFLD) in developed countries is 30% in the general population and 50% in patients with type 2 diabetes mellitus (T2DM). The aim of this study was to compare the seventy of NAFLD, as assessed by liver biopsy and using the non-invasive index NAFLD Fibrosis Score (NFS), in subjects with and without T2DM.Patients and methods: The study sample consisted of 217 patients with biopsy-proven NAFLD. Anthropometric assessments, laboratory tests, histological criteria established by the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), and the NFS were recorded.Results: Patients with T2DM (n = 36; 16.5%) had higher HOMA-IR values (6.3 +/- 3.6 vs. 3.3 +/- 2.4; p