Measurement of the uniaxial mechanical properties of healthy and atherosclerotic human coronary arteries
Measurement of the uniaxial mechanical properties of healthy and atherosclerotic human coronary arteries
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DOI：
10.1016/j.msec.2013.02.016
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发表时间：
2013-07-01
影响因子：
7.9
通讯作者：
Faghihi, Shahab
中科院分区：
文献类型：
--
作者：
Karimi, Alireza;Navidbakhsh, Mahdi;Faghihi, Shahab
动脉粥样硬化是一种常见的动脉疾病，会改变动脉壁的僵硬程度。动脉僵硬与许多心血管疾病有关。本研究测量了22条人体冠状动脉的最大应力和应变，以及生理和最大弹性模数。此外，还获得了人体冠状动脉的力-位移图，以区分健康和动脉粥样硬化的动脉壁僵硬的变化。还考虑了每个标本的年龄及其对人体冠状动脉弹性模数的影响。在死后5小时内切除22条人类冠状动脉，其中包括8条动脉粥样硬化动脉和14条健康动脉。将样品安装在拉伸测试机上，施加压力，直到发生断裂。计算每个样本的弹性模量系数，以比较健康冠状动脉和动脉粥样硬化冠状动脉的硬度。结果表明，与正常动脉相比，动脉粥样硬化动脉的应力增加44.55%，应变减少34.61%。健康动脉的生理弹性模数和最大弹性模数分别是动脉粥样硬化的2.53倍和2.91倍。标本的年龄与动脉壁硬度无相关性。生物力学和数学的结合被用来表征人类冠状动脉的机械特性。这些结果可用于了解冠状动脉的延伸和破裂机制，并对介入治疗和外科手术，包括球囊血管成形术、搭桥术和支架置入术具有一定的指导意义。(C)2013爱思唯尔B.V.保留所有权利。
Atherosclerosis is a common arterial disease which alters the stiffness of arterial wall. Arterial stiffness is related to many cardiovascular diseases. In this investigation, maximum stress and strain as well as physiological and maximum elastic modulus of 22 human coronary arteries are measured. In addition, the force-displacement diagram of human coronary artery is obtained to discern the alterations between the healthy and atherosclerotic arterial wall stiffness. The age of each specimen and its effect on the elastic modulus of human coronary arteries is also considered. Twenty-two human coronary arteries, including eight atherosclerotic and fourteen healthy arteries are excised within 5 hours post-mortem. Samples are mounted on a tensile-testing machine and force is applied until breakage occurs. Elastic modulus coefficient of each specimen is calculated to compare the stiffness of healthy and atherosclerotic coronary arteries. The results show that the atherosclerotic arteries bear 44.55% more stress and 34.61% less strain compared to the healthy ones. The physiological and maximum elastic moduli of healthy arteries are 2.53 and 2.91 times higher than that of atherosclerotic arteries, respectively. The age of specimens show no correlation with the arterial wall stiffness. A combination of biomechanics and mathematics is used to characterize the mechanical properties of human coronary arteries. These results could be utilized to understand the extension and rupture mechanism of coronary arteries and has implications for interventions and surgeries, including balloon-angioplasty, bypass, and stenting. (C) 2013 Elsevier B.V. All rights reserved.