Human papillomavirus genotypes associated with cervical cytologic abnormalities and HIV infection in Ugandan women
Human papillomavirus genotypes associated with cervical cytologic abnormalities and HIV infection in Ugandan women
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DOI：
10.1002/jmv.20817
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发表时间：
2007-06-01
影响因子：
12.7
通讯作者：
Salata, R. A.
中科院分区：
文献类型：
--
作者：
Blossom, D. B.;Beigi, R. H.;Salata, R. A.
人乳头状病毒（HPV）感染几乎与所有宫颈癌病例相关，而宫颈癌是发展中国家女性的常见恶性肿瘤。进行了一项横断面研究，以确定在乌干达坎帕拉性传播感染诊所就诊的女性中 HPV 感染、人类免疫缺陷病毒 (HIV) 感染和宫颈细胞学异常的患病率。 2002 年 6 月和 7 月，135 名女性接受了全面的体检，包括巴氏涂片检查。通过血清学评估HIV状况。临床医生采集宫颈和阴道拭子，并通过 PCR/反向印迹条检测检测 HPV 基因型。在 106 名宫颈拭子足以进行 HPV 检测的女性中，HPV 患病率为 46.2% (49/106)。 HIV 感染率为 34.9% (37/106)。高风险基因型 52、58 和 16 是最常检测到的基因型。 18% (9/49) 感染 HPV 的女性被发现具有基因型 16 和/或 18。73% (27/37) 的 HIV 阳性女性和 16% (10/63) 的 HIV 阴性女性的子宫颈抹片检查异常 (P < 0.0001)。在 HIV 阳性女性中，子宫颈抹片检查异常与高危 HPV 基因型的存在相关（P < 0.001）。大多数在乌干达性传播感染诊所就诊的感染 HPV 的女性都感染了 16 和 18 型以外的高风险 HPV 基因型。未来的研究应重点关注当前仅限于高风险基因型 16 和 18 的 HPV 疫苗配方是否能有效减轻该人群患宫颈癌的负担。 J. Med。病毒。 79:758-765, 2007。(C) 2007 Wiley-Liss, Inc.
Human papillornavirus (HPV) infection is associated with almost all cases of cervical cancer, and cervical cancer is a common malignancy in women living in developing countries. A cross-sectional study was conducted to determine the prevalence of HPV infection, human immunodeficiency virus (HIV) infection, and cervical cytologic abnormalities in women presenting to a sexually transmitted infections clinic in Kampala, Uganda. In June and July, 2002, 135 women underwent complete physical exams including Papanicolaou (Pap) smears. HIV status was evaluated by serology. Cervical and vaginal swabs were obtained by clinicians and tested for HPV genotypes by PCR/reverse blot strip assay. Of the 106 women with cervical swabs adequate for HPV testing, the HPV prevalence was 46.2% (49/106). HIV prevalence was 34.9% (37/106). High risk genotypes 52, 58, and 16 were the genotypes detected most commonly. Eighteen percent (9/49) of women infected with HPV were found to have genotypes 16 and/or 18. Seventy-three percent (27/37) of HIV-positive women versus 16% (10/63) of HIV-negative women had abnormal Pap smears (P < 0.0001). Among HIV-positive women, abnormal Pap smears were associated with the presence of high risk HPV genotypes (P < 0.001). The majority of women infected with HPV attending this sexually transmitted infections clinic in Uganda were infected with high risk HPV genotypes other than 16 and 18. Future studies should focus on whether current HPV vaccine formulations, that are limited to high risk genotypes 16 and 18, would be effective at decreasing the burden of cervical cancer in this population. J. Med. Virol. 79:758-765, 2007. (C) 2007 Wiley-Liss, Inc.