Clinical importance of confirming or excluding the diagnosis of chronic graft-versus-host disease
Clinical importance of confirming or excluding the diagnosis of chronic graft-versus-host disease
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DOI：
10.1038/sj.bmt.1703278
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发表时间：
2001-12-01
影响因子：
4.8
通讯作者：
Vogelsang, GB
中科院分区：
文献类型：
--
作者：
Jacobsohn, DA;Montross, S;Vogelsang, GB
慢性移植物抗宿主病（cGVHD）是异基因造血细胞移植的主要并发症。本病的表现是多种多样的，需要组织学确诊。此外，cGVHD通常可以模仿其他疾病，反之亦然。我们对1994年至1998年在约翰霍普金斯肿瘤中心转介到GVHD诊所的123例诊断为活动性cGVHD的患者进行了回顾性分析。其中，9例患者（7%）没有cGVHD的证据，25例患者（20%）有非活动性cGVHD。这些患者中的许多人被发现有其他过程占他们的持续症状。我们的结论是，由于这种疾病的治疗有显着的毒性，因为什么似乎代表cGVHD实际上可能是另一种疾病，正确诊断cGVHD或排除这种诊断是必不可少的。
Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic cell transplantation. The presentation of this disease is varied, and it requires histological confirmation for diagnosis. In addition, cGVHD can often mimic other diseases, and vice versa. We have conducted a retrospective analysis of 123 patients referred to the GVHD clinic at the Johns Hopkins Oncology Center from 1994 to 1998 with a diagnosis of active cGVHD. Of these, nine patients (7%) had no evidence of cGVHD, and 25 patients (20%) had inactive cGVHD. Many of these patients were found to have other processes accounting for their ongoing symptoms. We conclude that since the therapy for this disease has significant toxicities and since what appears to represent cGVHD may actually be another disease, correct diagnosis of cGVHD or exclusion of this diagnosis is essential.