Abnormal antibody responses in patients with persistent generalized lymphadenopathy.
Abnormal antibody responses in patients with persistent generalized lymphadenopathy.
复制标题
持续性全身淋巴结肿大患者的抗体反应异常。
DOI：
10.1007/bf00915157
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发表时间：
1988
影响因子：
9.1
通讯作者：
Wedgwood,RJ
中科院分区：
文献类型：
--
作者：
Ochs,HD;Junker,AK;Collier,AC;Virant,FS;Handsfield,HH;Wedgwood,RJ
持续性全身性淋巴结病（PGL）是公认的人类免疫缺陷病毒（HIV）感染的组成部分。我们对7名HIV感染和PGL的同性恋男性进行了B和T细胞功能的纵向研究。通过对T依赖性新抗原噬菌体γX 174和匙孔血蓝蛋白（KLH）、T非依赖性十四价肺炎球菌多糖疫苗以及回忆抗原免疫后的体内抗体反应进行连续评估，所有七人都出现了异常抗体介导的免疫。白喉和破伤风类毒素。与HIV阴性的异性恋对照组相比，PGL患者的抗体滴度较低，并且在用噬菌体免疫后，未能发展免疫记忆并从IgM同种型抗体转换为IgG同种型抗体。免疫力低下的程度与临床状况之间存在相关性;那些症状最严重的人表现出最广泛的免疫缺陷。然而，尽管有明显的免疫功能障碍，7名男性中有5名在3年的随访期内保持临床稳定。
Persistent, generalized lymphadenopathy (PGL) is a recognized component of human immunodeficiency virus (HIV) infection. We conducted longitudinal studies of B and T cell function in seven homosexual men with HIV infection and PGL. All seven had abnormal antibody-mediated immunity as studied by sequential assessment ofin vivoantibody responses after immunization with the T-dependent neoantigens bacteriophage γX 174 and key-hole limpet hemocyanin (KLH), the T-independent tetradecavalent pneumococcal polysaccharide vaccine, and the recall antigens diphtheria and tetanus toxoid. Compared to HIV-negative heterosexual controls, PGL patients responded with lower antibody titers and, following immunization with phage, failed to develop immunologic memory and to switch from IgM- to IgG-isotype antibody.In vitroantigen-induced antibody production was markedly diminished; and some patients showed depressed mitogen responses. There was a correlation between the degree of compromised immunity and the clinical condition; those with the most severe symptoms showed the most extensive immune deficiency. Yet despite obvious immunologic impairment, five of the seven men have remained clinically stable over a 3-year follow-up period.