Adult height in relation to mortality from 14 cancer sites in men in London (UK): evidence from the original Whitehall study
Adult height in relation to mortality from 14 cancer sites in men in London (UK): evidence from the original Whitehall study
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DOI：
10.1093/annonc/mdj018
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发表时间：
2006-01-01
影响因子：
50.5
通讯作者：
Smith, GD
中科院分区：
文献类型：
--
作者：
Batty, GD;Shipley, MJ;Smith, GD
背景：在相对较少的研究中，成人身高与器官特异性恶性肿瘤有关。一些地点的研究结果是不一致的，一些研究受到一系列方法上的限制。材料和方法：我们使用来自白厅队列的原始数据，研究了成人身高与14种癌症部位的死亡之间的关系。这是一项前瞻性研究，研究对象是18403名中年非工业男性政府雇员，他们在20世纪60年代末接受了调查，然后对死亡率进行了最长35年的跟踪调查。结果：随访期间死亡11099人，其中3101人（28%）死于癌症。Cox比例风险回归模型显示身高对部位特异性癌症的影响不大。在对包括就业等级（社会经济地位的一个指标）、体重指数和吸烟习惯在内的协变量进行调整后，身高增加与合并部位癌症死亡率升高相关[身高每增加5厘米的危险比（95%置信区间）；不同高度类别的趋势P为1.05 (1.03,1.08)；P < 0.001]，肺[1.13 (1.06,1.20)；P < 0.001]，前列腺[1.07 (0.99,1.15)；P = 0.08]，肾[1.20](0.99,1.46)；P = 0.08]，皮肤[1.35 (1.06,1.70)；P = 0.02]和白血病[1.11 (0.96,1.28)；P = 0.02]。结论：在其他解释中，此处明显的弱阳性身高-癌症梯度可能归因于与成年身高相关的早期生活暴露，例如高热量摄入。
Background: Adult height has been related to organ-specific malignancies in relatively few studies. Findings are discrepant for some sites and several studies are subject to a series of methodological limitations.Materials and methods: We examined the association of adult height with death attributed to 14 cancer sites using data from the original Whitehall cohort. This is a prospective study of 18 403 middle-aged, non-industrial, London-based, male government employees who were examined in the late 1960s and then followed up for mortality for a maximum of 35 years.Results: There were 11 099 deaths during follow-up, 3101 (28%) of which were ascribed to cancer. Cox proportional hazards regression models revealed modest effects for height in relation to site-specific cancers. Following adjustment for covariates that included employment grade (an indicator of socioeconomic position), body mass index and smoking habit, increased height was associated with elevated mortality rates for cancer of combined sites [hazards ratio per 5 cm increase in height (95% confidence interval); P for trend across height categories: 1.05 (1.03, 1.08); P < 0.001], lung [1.13 (1.06, 1.20); P < 0.001], prostate [1.07 (0.99, 1.15); P = 0.08], kidney [1.20 (0.99, 1.46); P = 0.08], skin [1.35 (1.06, 1.70); P = 0.02] and leukaemia [1.11 (0.96, 1.28); P = 0.02].Conclusions: Amongst other explanations, the weak positive height-cancer gradients apparent herein may be ascribed to early life exposures that correlate with adult height, such as high caloric intake.