Is it my cancer or am i just getting older?: Impact of cancer on age-related health conditions of older cancer survivors
Is it my cancer or am i just getting older?: Impact of cancer on age-related health conditions of older cancer survivors
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DOI：
10.1002/cncr.29914
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发表时间：
2016-06-15
期刊：
影响因子：
6.2
通讯作者：
Reeve, Bryce B.
中科院分区：
文献类型：
--
作者：
Leach, Corinne R.;Bellizzi, Keith M.;Reeve, Bryce B.
癌症恶化或产生新的健康状况的程度是一个长期悬而未决的问题。目前的前瞻性研究探讨了癌症的功能，发展和恶化的年龄相关的健康状况之间的老年人发展癌症与年龄匹配的controls.METHODSSurveillance，流行病学和最终结果登记数据的短期影响与医疗保险健康结果调查（MHOS）数据。共有921例符合条件的病例是医疗保险受益人，在基线和随访MHOS之间诊断为乳腺癌、结直肠癌、肺癌或前列腺癌。使用倾向评分匹配，从MHOS匹配4605例无癌症对照。协方差分析和逻辑回归分析用于检查与对照组相比，病例组的身体功能、日常生活活动、年龄相关疾病和原有疾病的恶化的变化。与对照组相比，NSCLC组的日常生活活动和身体功能下降更大（平均值，-1.53 [标准误差，0.14]），肺癌患者的变化最大（平均值，-6.72 [标准误差，0.94]）。癌症诊断增加了抑郁症的风险，但不会增加手部和/或臀部关节炎，尿失禁（前列腺癌除外）或视力和/或听力问题的几率。有一个癌症的诊断也没有加剧关节炎或足neuropathy.CONCLUSIONSThe的研究结果表明，癌症是一个更强大的驱动程序的身体功能下降和老年人抑郁症的风险增加。需要采取干预措施来降低这些风险。临床医生需要为患者和家庭做好准备，以适应功能水平的变化，并采取干预措施，限制老年癌症患者的下降。Cancer 2016;122：1946-53. (c)2016年美国癌症协会。目前的前瞻性研究探讨了癌症对老年人患癌症与年龄匹配对照组相比的功能，发展和年龄相关健康状况恶化的影响。研究结果表明，癌症是老年人身体功能下降和抑郁风险增加的更强驱动力。
BACKGROUNDThe extent to which cancer exacerbates or creates new health conditions is a long-standing, unanswered question. The current prospective study examined the short-term impact of cancer on the functioning, development of, and worsening of age-related health conditions among older adults who develop cancer compared with age-matched controls.METHODSSurveillance, Epidemiology, and End Results registry data were linked with Medicare Health Outcomes Survey (MHOS) data. A total of 921 eligible cases were Medicare beneficiaries with diagnosis of breast, colorectal, lung, or prostate cancer made between their baseline and follow-up MHOS. Using propensity score matching, 4605 controls without cancer were matched from the MHOS. Analysis of covariance and logistic regression were used to examine changes in physical functioning, activities of daily living, age-related conditions, and exacerbation of preexisting conditions for cases compared with controls.RESULTSCancer groups demonstrated greater declines in activities of daily living and physical function compared with controls (mean, -1.53 [standard error, 0.14]), with the greatest change noted for patients with lung cancer (mean, -6.72 [standard error, 0.94]). Having a cancer diagnosis increased the risk of depression but did not increase the odds of developing arthritis in the hand and/or hip, urinary incontinence (except for prostate cancer), or vision and/or hearing problems. Having a cancer diagnosis also did not exacerbate the severity of arthritis or foot neuropathy.CONCLUSIONSThe findings of the current study suggest that cancer is a stronger driver for declines in physical functioning and an increased risk of depression in older adults. Interventions are needed to decrease these risks. Clinicians need to prepare patients and families for changes in functioning levels and interventions that limit the declines for older patients with cancer are needed. Cancer 2016;122:1946-53. (c) 2016 American Cancer Society.The current prospective study examines the impact of cancer on the functioning, development of, and worsening of age-related health conditions among older adults who develop cancer compared with age-matched controls. The findings suggest that cancer is a stronger driver for declines in physical functioning and an increased risk of depression in older adults.