Olmsted syndrome: The clinical spectrum of mutilating palmoplantar keratoderma
Olmsted syndrome: The clinical spectrum of mutilating palmoplantar keratoderma
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DOI：
10.1046/j.1525-1470.2003.20410.x
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发表时间：
2003-07-01
影响因子：
1.5
通讯作者：
Rivitti, EA
中科院分区：
文献类型：
--
作者：
Bergonse, FN;Rabello, SM;Rivitti, EA
奥姆斯特德综合征是一种罕见的遗传模式不明的过绿性掌跖角化病。它开始于新生儿期或儿童时期，并有一个渐进和极端致残的过程。我们报告了两个新的，没有血缘关系的Olmsted综合征患者，一个有疾病的早期体征和症状，另一个在30年的随访期中显示了综合征的全面谱系。
Olmsted syndrome is a rare variety of transgredient palmoplantar keratoderma with an undefined inheritance pattern. It starts in the neonatal period or in childhood and has a progressive and extremely disabling course. We report two new, unrelated patients with Olmsted syndrome, one with the early signs and symptoms of the disorder, the other showing the full-blown spectrum of the syndrome during a 30-year follow-up period.