Fly meets yeast: checking the correct orientation of cell division.
Fly meets yeast: checking the correct orientation of cell division.
复制标题
苍蝇遇见酵母：检查细胞分裂的正确方向。
DOI：
10.1016/j.tcb.2011.05.004
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发表时间：
2011
影响因子：
19
通讯作者：
Yamashita,YukikoM
中科院分区：
文献类型：
--
作者：
Pereira,Gislene;Yamashita,YukikoM
细胞分裂通常被认为是一个过程，通过精确复制母细胞的基因组DNA，使细胞器加倍，并将其分离成两个细胞，从而产生与母细胞完全相同的副本。然而，从细菌到人类细胞的许多细胞类型都不对称分裂，以产生具有不同特征的子细胞。这种不对称分裂是细胞寿命、胚胎发育和干细胞稳态的基础。不对称分裂需要细胞不对称和细胞分裂机制的协调。越来越多的证据表明，控制这一过程的基本分子机制从酵母到人类都是保守的。在这篇综述中，我们强调了酵母和果蝇生殖系干细胞（GSCs）不对称细胞分裂机制的相似性，希望从中提取出几种系统背后的共同主题。
Cell division is generally thought to be a process that produces an exact copy of the mother cell by precisely replicating its genomic DNA, doubling organelles, and segregating them into two cells. Many cell types from bacteria to human cells divide asymmetrically, however, to generate daughter cells with distinct characteristics. Such asymmetric divisions are fundamental to the lifespan of a cell, to embryonic development, and to stem cell homeostasis. Asymmetric division requires coordination of cellular asymmetry and the cell division machinery. Accumulating evidence suggests that the basic molecular mechanisms that govern this process are conserved from yeast to humans. In this review we highlight similarities in the mechanisms of asymmetric cell division in yeast andDrosophilamale germline stem cells (GSCs) in the hope of extracting common themes underlying several systems.