Notch and T cell malignancy
Notch and T cell malignancy
复制标题
DOI：
10.1016/j.semcancer.2004.04.012
复制
发表时间：
2004-10-01
影响因子：
14.5
通讯作者：
Pear, WS
中科院分区：
文献类型：
--
作者：
Zweidler-McKay, PA;Pear, WS
Notch信号是正常T细胞发育所必需的。然而，Notch表达必须被精确调节，因为组成型Notch信号传导导致T细胞淋巴瘤。最近的证据提供了深入了解Notch介导的淋巴瘤发生及其与T细胞发育的关系的潜在机制。有证据表明，Notch可能与几个重要的细胞通路相互作用，并在淋巴瘤发生过程中与其他癌基因合作。特别地，Notch似乎调节前TCR信号传导，抑制E2 A途径，并且在鼠白血病模型中，经常与Myc、E2 A-PBX和显性负性Ikaros失调协作。本文就Notch介导的T细胞淋巴瘤发生机制的研究进展作一综述。(C)2004爱思唯尔有限公司保留所有权利。
Notch signaling is required for normal T cell development. However, Notch expression must be precisely regulated as constitutive Notch signaling leads to T cell lymphomas. Recent evidence has provided insights into potential mechanisms of Notch-mediated lymphomagenesis and its relationship to T cell development. The evidence suggests that Notch likely interacts with several important cellular pathways and can cooperate with other oncogenes during lymphomagenesis. In particular, Notch appears to modulate pre-TCR signaling, inhibit the E2A pathway, and in murine leukemia models, frequently cooperates with Myc, E2A-PBX and dominant negative Ikaros dysregulation. This review will present current knowledge in these areas and explore theories on Notch-mediated T cell lymphomagenesis. (C) 2004 Elsevier Ltd. All rights reserved.