Magnetite Fe3O4 Has no Intrinsic Peroxidase Activity, and Is Probably not Involved in Alzheimer's Oxidative Stress
Magnetite Fe3O4 Has no Intrinsic Peroxidase Activity, and Is Probably not Involved in Alzheimer's Oxidative Stress
复制标题
DOI：
10.1002/anie.201807676
复制
发表时间：
2018-11-05
影响因子：
16.6
通讯作者：
Robert, Anne
中科院分区：
文献类型：
--
作者：
Gumpelmayer, Michelle;Nguyen, Michel;Robert, Anne
尽管在一些被高度引用的文章中指出，磁铁矿是没有过氧化物酶活性的。事实上，这种非常稳定的混合价(FeO)-O-II中心点(Fe2O)-O-III络合物不能催化氧化标准的过氧化物酶底物，特别是在生物相关的pH值为7.4时。此外，磁铁矿的有害氧化还原活性已被怀疑在阿尔茨海默病的大脑损伤，在体外不与淀粉样肽Aβ显著相互作用，并且无论存在或不存在Aβ，都不能诱导氧化应激的第一步--氧的还原激活。事实上，这种高度不溶的矿物质铁衍生物可能并不参与AD患者脑神经元的氧化损伤。
Despite stated in some highly cited articles, magnetite is devoided of peroxidase activity. In fact, this very stable mixed valence (FeO)-O-II center dot(Fe2O3)-O-III complex is not catalytically competent to oxidize standard peroxidase substrates, especially at the biologically relevant pH value of 7.4. In addition, magnetite whose deleterious redox activity has been suspected in Alzheimer's disease brain damages, does not significantly interact with amyloid peptide A beta in vitro, and is not able to induce, either in the presence or absence of A beta, the reductive activation of dioxygen, the first step of an oxidative stress. In fact, this highly insoluble mineral iron derivative is probably not involved in the oxidative damage of brain neurons of patients with AD.