Computation of hemodynamics in the left coronary artery with variable angulations
Computation of hemodynamics in the left coronary artery with variable angulations
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DOI：
10.1016/j.jbiomech.2011.04.033
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发表时间：
2011-07-07
影响因子：
2.4
通讯作者：
Jewkes, James
中科院分区：
文献类型：
--
作者：
Chaichana, Thanapong;Sun, Zhonghua;Jewkes, James
本研究的目的是研究左冠状动脉的角度变化的血流动力学效应，基于模拟和现实的冠状动脉模型。共生成12个模型，包括4个真实冠状动脉和8个模拟冠状动脉几何形状，包括左主干、左前降支和左回旋支。模拟模型包括各种冠状动脉角度，即15度、30度、45度、60度、75度、90度、105度和120度。真实的冠状动脉角度是基于选定患者的数据，角度范围从58度和73度的窄角到110度和120度的广角。进行计算流体动力学分析以模拟反映体内心脏血流动力学的真实生理条件。在模拟和真实模型中测量了心动周期中的壁面切应力、壁面切应力梯度、速度流态和壁面压力。我们的研究结果表明，一个扰动的流动模式，观察模型与更广泛的角度，壁面压力被发现时，从左主干分叉区域的流动变化，根据模拟和现实模型。在宽角度的左分叉处显示出低的壁面剪应力梯度。基于真实和模拟模型，冠状动脉成角与随后的血流动力学变化之间存在直接相关性。我们的研究结果还需要进一步的研究来验证，这些研究是基于不同冠状动脉疾病严重程度的患者。(C)2011爱思唯尔有限公司保留所有权利。
The purpose of this study was to investigate the hemodynamic effect of variations in the angulations of the left coronary artery, based on simulated and realistic coronary artery models. Twelve models consisting of four realistic and eight simulated coronary artery geometries were generated with the inclusion of left main stem, left anterior descending and left circumflex branches. The simulated models included various coronary artery angulations, namely, 15 degrees, 30 degrees, 45 degrees, 60 degrees, 75 degrees, 90 degrees, 105 degrees and 120 degrees. The realistic coronary angulations were based on selected patient's data with angles ranging from narrow angles of 58 degrees and 73 degrees to wide angles of 110 degrees and 120 degrees. Computational fluid dynamics analysis was performed to simulate realistic physiological conditions that reflect the in vivo cardiac hemodynamics. The wall shear stress, wall shear stress gradient, velocity flow patterns and wall pressure were measured in simulated and realistic models during the cardiac cycle. Our results showed that a disturbed flow pattern was observed in models with wider angulations, and wall pressure was found to reduce when the flow changed from the left main stem to the bifurcated regions, based on simulated and realistic models. A low wall shear stress gradient was demonstrated at left bifurcations with wide angles. There is a direct correlation between coronary angulations and subsequent hemodynamic changes, based on realistic and simulated models. Further studies based on patients with different severities of coronary artery disease are required to verify our results. (C) 2011 Elsevier Ltd. All rights reserved.