Two's company, three's a crowd:: can H2S be the third endogenous gaseous transmitter?
Two's company, three's a crowd:: can H2S be the third endogenous gaseous transmitter?
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DOI：
10.1096/fj.02-0211hyp
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发表时间：
2002-11-01
期刊：
影响因子：
4.8
通讯作者：
Wang, R
中科院分区：
文献类型：
--
作者：
Wang, R
硫化氢（H2S）是一种致命的“臭鸡蛋气体”，它可以在许多类型的哺乳动物细胞中产生。在功能上，H2S与海马长时程增强、脑发育和血压调节的诱导有关。通过特异性作用于K-ATP通道，H2S可以使细胞膜增生，松弛平滑肌细胞或降低神经元兴奋性。H2S的内源性代谢和生理功能将这种气体很好地定位于内源性气体递质的新家族中，称为“气体递质”。“据推测，H2S是第三个内源性信号气体递质，除了一氧化氮和一氧化碳。H2S的这一定位将打开一个令人兴奋的领域-H2S生理学-包括实现H2S和其他气体递质的相互作用，蛋白质的硫化修饰，以及H2S在多个系统中的功能作用。这一结果可能有助于阐明许多与H2S代谢异常有关的疾病的发病机制。
Bearing the public image of a deadly "gas of rotten eggs," hydrogen sulfide (H2S) can be generated in many types of mammalian cells. Functionally, H2S has been implicated in the induction of hippocampal long-term potentiation, brain development, and blood pressure regulation. By acting specifically on K-ATP channels, H2S can hyperpolarize cell membranes, relax smooth muscle cells, or decrease neuronal excitability. The endogenous metabolism and physiological functions of H2S position this gas well in the novel family of endogenous gaseous transmitters, termed "gasotransmitters." It is hypothesized that H2S is the third endogenous signaling gasotransmitter, besides nitric oxide and carbon monoxide. This positioning of H2S will open an exciting field-H2S physiology-encompassing realization of the interaction of H2S and other gasotransmitters, sulfurating modification of proteins, and the functional role of H2S in multiple systems. It may shed light on the pathogenesis of many diseases related to the abnormal metabolism of H2S.