Functional convergence of response properties in the auditory thalamocortical system
Functional convergence of response properties in the auditory thalamocortical system
复制标题
DOI：
10.1016/s0896-6273(01)00445-7
复制
发表时间：
2001-10-11
期刊：
影响因子：
16.2
通讯作者：
Schreiner, CE
中科院分区：
文献类型：
--
作者：
Miller, LM;Escabí, MA;Schreiner, CE
大脑的基本任务之一是构建和转换动物环境的表征，但很少有研究描述单个神经元如何完成这一任务。我们的研究结果从相关对在听觉丘脑皮层系统表明，皮层兴奋性感受野区域可以直接从丘脑遗传，从较小的输入，并组装的合作活动的神经元合奏。功能性丘脑皮质连接的流行率严格受tonotopy，但连接强度不是。最后，皮层的频谱和时间调制偏好可能与丘脑输入有很大不同。我们的观察揭示了从听觉丘脑到皮层的反应属性的根本重建，并说明了一些属性是如何传播的，而其他显着的转换或产生的皮质内具有很大的保真度。
One of the brain's fundamental tasks is to construct and transform representations of an animal's environment, yet few studies describe how individual neurons accomplish this. Our results from correlated pairs in the auditory thalamocortical system show that cortical excitatory receptive field regions can be directly inherited from thalamus, constructed from smaller inputs, and assembled by the cooperative activity of neuronal ensembles. The prevalence of functional thalamocortical connectivity is strictly governed by tonotopy, but connection strength is not. Finally, spectral and temporal modulation preferences in cortex may differ dramatically from the thalamic input. Our observations reveal a radical reconstruction of response properties from auditory thalamus to cortex, and illustrate how some properties are propagated with great fidelity while others are significantly transformed or generated intracortically.