A compendium of cytogenetic abnormalities in myelofibrosis: molecular and phenotypic correlates in 826 patients
A compendium of cytogenetic abnormalities in myelofibrosis: molecular and phenotypic correlates in 826 patients
复制标题
DOI：
10.1111/bjh.13260
复制
发表时间：
2015-04-01
影响因子：
6.5
通讯作者：
Tefferi, Ayalew
中科院分区：
文献类型：
--
作者：
Wassie, Emnet;Finke, Christy;Tefferi, Ayalew
在826例原发性骨髓纤维化（PMF）和可分析中期患者中，352例（426%）存在核型异常，其中240例（682%）为单一异常，48例（136%）为复杂异常；最常见的异常是20q- (233%), 13q-(182%), +8(111%), +9(99%)，染色体1q+(97%)和-7/7q-(71%)。表型相关包括：核型异常伴贫血（P=002），白细胞减少（P=002）
Among 826 patients with primary myelofibrosis (PMF) and analysable metaphases on cytogenetic studies, 352 (426%) had abnormal karyotype, of which 240 (682%) were sole aberrations and 48 (136%) were complex; the most frequent abnormalities were 20q- (233%), 13q- (182%), +8 (111%), +9 (99%), chromosome 1q+ (97%) and -7/7q- (71%). Phenotypic correlates included: abnormal karyotype with anaemia (P=002), leucopenia (P