Developmental Vitamin D Deficiency and Risk of Schizophrenia: A 10-Year Update
Developmental Vitamin D Deficiency and Risk of Schizophrenia: A 10-Year Update
复制标题
DOI：
10.1093/schbul/sbq101
复制
发表时间：
2010-11-01
影响因子：
6.6
通讯作者：
Eyles, Darryl W.
中科院分区：
文献类型：
--
作者：
McGrath, John J.;Burne, Thomas H.;Eyles, Darryl W.
迫切需要生成和测试可以解释精神分裂症发病率梯度的候选风险因素。根据流行病学线索，我们提出发育性维生素 D 缺乏可能会增加患精神分裂症的风险。这一假设可以解释不同的流行病学发现，包括出生季节、发病率和患病率的纬度梯度、深色皮肤移民前往某些国家的风险增加以及城乡梯度。动物实验表明，短暂的产前维生素 D 缺乏症与大脑结构和功能的持续变化有关，包括多巴胺能功能改变的证据。最近一项基于新生儿血液样本的病例对照研究发现，新生儿维生素 D 状态与精神分裂症风险之间存在显着关联。本文简要总结了探索这一假设的流行病学和动物实验研究。
There is an urgent need to generate and test candidate risk factors that may explain gradients in the incidence of schizophrenia. Based on clues from epidemiology, we proposed that developmental vitamin D deficiency may contribute to the risk of developing schizophrenia. This hypothesis may explain diverse epidemiological findings including season of birth, the latitude gradients in incidence and prevalence, the increased risk in dark-skinned migrants to certain countries, and the urban-rural gradient. Animal experiments demonstrate that transient prenatal hypovitaminosis D is associated with persisting changes in brain structure and function, including convergent evidence of altered dopaminergic function. A recent case-control study based on neonatal blood samples identified a significant association between neonatal vitamin D status and risk of schizophrenia. This article provides a concise summary of the epidemiological and animal experimental research that has explored this hypothesis.