Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
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DOI：
10.1126/science.275.5298.400
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发表时间：
1997-01-17
期刊：
影响因子：
56.9
通讯作者：
Bohmann, D
中科院分区：
文献类型：
--
作者：
Musti, AM;Treier, M;Bohmann, D
原癌基因编码的转录因子c-Jun响应于通过丝裂原活化蛋白激酶（MAPK）信号转导途径起作用的许多诱导剂而激活基因。MAPK磷酸化后c-Jun的活化伴随着c-Jun泛素化的减少和随后的蛋白质稳定化。这些结果说明了调节蛋白质降解在信号依赖性中央oi基因表达中的相关性。
The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a number of inducers that act through mitogen-activated protein kinase (MAPK) signal transduction pathways. The activation of c-Jun after phosphorylation by MAPK is accompanied by a reduction in c-Jun ubiquitination and consequent stabilization of the protein. These results illustrate the relevance of regulated protein degradation in the signal-dependent central oi gene expression.