No Association of Vascular Endothelial Growth Factor-A (VEGF-A) and VEGF-C Expression with Survival in Patients with Gastric Cancer
No Association of Vascular Endothelial Growth Factor-A (VEGF-A) and VEGF-C Expression with Survival in Patients with Gastric Cancer
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DOI：
10.4143/crt.2009.41.4.218
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发表时间：
2009-12-01
影响因子：
4.6
通讯作者：
Yu, Wansik
中科院分区：
文献类型：
--
作者：
Lee, Soo Jung;Kim, Jong Gwang;Yu, Wansik
虽然血管内皮生长因子（VEGF）超家族已被证实对肿瘤相关血管生成有重要影响，但VEGF在胃癌中表达的预后意义仍存在争议。因此，本研究分析了VEGF-A和VEGF-C的表达及其对胃癌患者预后的影响。Materials and Methods 375例连续接受手术切除术的胃腺癌患者纳入本研究。结果VEGF-A和VEGF-C阳性表达分别为337例（90.1%）和278例（74.9%）。生存分析显示VEGF-A和VEGF-C的表达对OS和DFS无影响。在多变量分析，包括年龄，性别和TNM分期，没有显着关联的VEGF-A或VEGF-C的表达和survival.ConclusionThe目前的研究表明，组织表达的VEGF-A或VEGF-C单独手术切除的胃腺癌患者是一个独立的预后标志物之间的等级观察。
PurposeAlthough the vascular endothelial growth factor (VEGF) superfamily has been identified to critically influence tumor-related angiogenesis, the prognostic significance of a VEGF expression in gastric cancer is still controversial. Accordingly, the present study analyzed the VEGF-A and VEGF-C expressions and their impact on the prognosis of patients with gastric cancer.Materials and MethodsThree hundred seventy-five consecutive patients who underwent surgical resection for gastric adenocarcinoma with a curative intent were enrolled in the present study. Immunohistochemical staining for VEGF-A and VEGF-C was performed using the formalin fixed, paraffin embedded tumor tissues.ResultsPositive VEGF-A and VEGF-C expressions were observed in 337 (90.1%) and 278 (74.9%) cases, respectively. The survival analysis showed that the expression of VEGF-A and VEGF-C had no effect on the OS and DFS. On the multivariate analysis that included age, gender and the TNM stage, no significant association between the grade of the VEGF-A or VEGF-C expression and survival was observed.ConclusionThe current study suggests that the tissue expression of VEGF-A or VEGF-C alone is not an independent prognostic marker for patients with surgically resected gastric adenocarcinoma.