BIAXIAL MECHANICAL-BEHAVIOR OF EXCISED VENTRICULAR EPICARDIUM
BIAXIAL MECHANICAL-BEHAVIOR OF EXCISED VENTRICULAR EPICARDIUM
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DOI：
10.1152/ajpheart.1990.259.1.h101
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发表时间：
1990-07-01
影响因子：
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通讯作者：
YIN, FCP
中科院分区：
文献类型：
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作者：
HUMPHREY, JD;STRUMPF, RK;YIN, FCP
我们报道了从犬心左、右室游离壁上分离的心外膜的体外双轴应力-应变实验结果。这些数据表明，室外膜的生物力学行为与心房心外膜和壁心包有质的相似之处，但不同于非收缩心肌。特别是，心外膜表现出高度非线性的应力-拉伸行为，最初是顺应性的，但后来非常僵硬，接近其延伸性的极限。此外，心外膜一开始似乎是各向同性的，但在快速硬化后变得明显的各向异性。最后，取自右室和左室游离壁的标本表现相似。我们认为，切除的心外膜能够承载显着的平面内负荷，有必要进一步研究其在局部和整体心脏力学和生理学中的作用。
We present results from in vitro biaxial stress-strain experiments on epicardium excised from the right and left ventricular free walls of canine hearts. These data reveal that the biomechanical behavior of ventricular epicardium is qualitatively similar to atrial epicardium and parietal pericardium but different from noncontracting myocardium. In particular, ventricular, epicardium exhibits a highly nonlinear stress-stretch behavior, being initially compliant but then very stiff near the limits of its extensibility. In addition, the epicardium appears to be initially isotropic but becomes markedly anisotropic upon rapid stiffening. Finally, specimens taken from the right and left ventricular free walls behaved similarly. We submit that excised ventricular epicardium is capable of carrying significant inplane loads and that there is a need to investigate further its role in local and global cardiac mechanics and physiology.