Airway hyperresponsiveness through synergy of γδ T cells and NKT cells
Airway hyperresponsiveness through synergy of γδ T cells and NKT cells
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DOI：
10.4049/jimmunol.179.5.2961
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发表时间：
2007-09-01
影响因子：
4.4
通讯作者：
Born, Willi K.
中科院分区：
文献类型：
--
作者：
Jin, Niyun;Miyahara, Nobuaki;Born, Willi K.
用卵清蛋白（OVA）致敏和激发小鼠，研究先天性T细胞在过敏性气道高反应性（AHR）发生中的作用。在T细胞缺陷小鼠中，少量共转移的γ（δ）T细胞和不变的NKT细胞可诱导AHR，但不诱导嗜酸性气道炎症，而单独使用这两种细胞类型均无效。只有V γ 1（+）V δ 5（+）γ δ T细胞增强AHR。令人惊讶的是，不需要OVA特异性α β T细胞，揭示了完全由先天性T细胞介导的AHR发育途径。这些数据表明，淋巴细胞协同作用，这是关键的Ag特异性适应性免疫反应，也是固有的T细胞依赖性先天性反应。
Mice sensitized and challenged with OVA were used to investigate the role of innate T cells in the development of allergic airway hyperresponsiveness (AHR). AHR, but not eosinophilic airway inflammation, was induced in T cell-deficient mice by small numbers of cotransferred gamma(delta) T cells and invariant NKT cells, whereas either cell type alone was not effective. Only V gamma 1(+)V delta 5(+) gamma delta T cells enhanced AHR. Surprisingly, OVA-specific alpha beta T cells were not required, revealing a pathway of AHR development mediated entirely by innate T cells. The data suggest that lymphocytic synergism, which is key to the Ag-specific adaptive immune response, is also intrinsic to T cell-dependent innate responses.