Uveal melanoma
Uveal melanoma
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DOI：
10.1053/j.semdp.2015.10.005
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发表时间：
2016-05-01
影响因子：
2.3
通讯作者：
Singh, Mithalesh
中科院分区：
文献类型：
--
作者：
Kashyap, Seema;Meel, Rachna;Singh, Mithalesh
葡萄膜黑色素瘤是成人最常见的原发性眼内恶性肿瘤。它与远处肿瘤的高扩散率和随之而来的死亡率有关。与视网膜母细胞瘤不同的是，在过去的几十年里，视网膜母细胞瘤的治疗进展导致了生存率的显著提高，而葡萄膜黑色素瘤患者的预后却没有改变。尽管肿瘤的局部控制有所改善，但大约50%的患者在15年内发展为转移性疾病。诊断的延迟和肿瘤明显的血管性可能是这种情况的基础。肿瘤的大小、位置、组织病理学表现、细胞遗传学异常和分子谱是预后的依据。修订后的第七版美国癌症联合委员会（AJCC）手册也提供了新的信息，可能会改善这一过程。在此，我们回顾了目前关于葡萄膜黑色素瘤的知识。(C) 2016 Elsevier Inc.版权所有。
Uveal melanoma is the most common primary intraocular malignancy in adults. It is associated with a high rate of distant tumor spread and consequent mortality. Unlike retinoblastoma, for which treatment advances over the last few decades have resulted in a dramatic improvement in survival, outcomes for patients with uveal melanoma remain unchanged. Despite improvement in local control of this tumor, roughly 50% of patients develop metastatic disease within 15 years. Delays in diagnosis and marked vascularity of this tumor may underlie that situation. Tumor size, location, histopathologic appearance, cytogenetic abnormalities, and molecular profiling are used in prognostication. The revised 7th edition of the American Joint Committee on Cancer (AJCC) manual has presented new information that may improve that process as well. Herein, we review current knowledge on uveal melanoma. (C) 2016 Elsevier Inc. All rights reserved.