Induction of dominant lethal mutation in male mice by ethyl alcohol
Induction of dominant lethal mutation in male mice by ethyl alcohol
复制标题
乙醇诱导雄性小鼠显性致死突变
作者：
F. Badr;R. S. Badr
已经有许多关于乙醇对生殖性能的影响以及这种关系的遗传方面的研究1 -10。但是，尽管在实验动物中对酒精偏好的遗传决定进行了广泛的研究，但对酒精消费的其他遗传方面的研究很少11 -13。长期以来，人们一直认为酒精不会对遗传造成危害。使用显性致死技术，我们发现在一定条件下给予小鼠乙醇可引起突变。
THERE have been many studies of the effects of ethyl alcohol on reproductive performance and of the genetic aspects of this relationship1–10. But in spite of extensive investigations of the genetic determination of alcohol preference in experimental animals, there has been little research on other genetic aspects of alcohol consumption11–13. It has been assumed for a long time that alcohol presents no genetic hazard. Using the dominant lethal technique, we have now found that in mice ethyl alcohol can be mutagenic when given under certain conditions.