Demography of sexually transmitted infections with vertical transmission
Demography of sexually transmitted infections with vertical transmission
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DOI：
10.1016/j.amc.2018.12.002
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发表时间：
2019-05-01
影响因子：
4
通讯作者：
Morita, Satoru
中科院分区：
文献类型：
--
作者：
Ito, Hiromu;Yamamoto, Taro;Morita, Satoru
性传播感染(STI)是一个持续的公共卫生问题。尽管作出了许多努力，性传播感染仍未根除。大多数性传播感染是通过“水平”性接触和“垂直”母婴传播。因此，我们需要探讨水平传播和垂直传播之间的数学关系，这对于战略性根除性病是必要的。在这里，我们构建了一个简单的模型来证明性传播感染的垂直传播动力学。我们提出了STI世代基本繁殖数(R-0)的新公式，并表明垂直传播对R-0的影响小于水平传播。我们还进行了基于代理的模拟来验证我们的理论预测。(C)2018年作者。由爱思唯尔公司出版。
Sexually transmitted infections (STIs) are an ongoing public health concern. Despite many efforts, STIs have not been eradicated. Most STIs are infected through "horizontal" sexual contact and "vertical" mother-to-child transmission. We therefore need to explore the mathematical relationship between horizontal and vertical transmissions, which is necessary for the strategic eradication of STIs. Here, we constructed a simple model to demonstrate the infection dynamics of STIs with vertical transmission. We proposed a new formulation of the basic reproduction number (R-0) for STIs over generations, and showed that vertical transmission exerts a smaller effect on the R-0 than horizontal transmission. We also performed agent-based simulations to validate our theoretical predictions. (C) 2018 The Authors. Published by Elsevier Inc.