Nuclear diacylglycerol kinases: regulation and roles.
Nuclear diacylglycerol kinases: regulation and roles.
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DOI：
10.2741/2704
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
D. Raben;B. Tu‐Sekine
中科院分区：
文献类型：
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作者：
D. Raben;B. Tu‐Sekine
二酰基甘油激酶是一个相关的脂质激酶家族。目前已知有10种二酰基甘油激酶同种异构体，根据其初级序列的相似性将其分为5类。所有这些酶催化ATP的-磷酸转移到脂质第二信使二酰基甘油，从而产生另一个脂质第二信使磷脂酸。因此，它们在调节这两种关键第二信使的相对水平方面具有独特的优势。这些酶在细胞和亚细胞分布上表现出相当大的多样性，这表明它们在生理功能上具有很大的多样性。有一个亚细胞区室受到了相当大的关注，那就是细胞核。许多dgk已被发现存在于细胞核中，或在激动剂作用下转移到细胞核中。在这篇综述中，我们主要关注核定位、内在酶活性的调节以及在细胞核中发现的六种二酰基甘油激酶的潜在生理作用：dgk - α、dgk - γ、dgk - δ、DGK-zeta、DGK-iota和DGK-theta。
The diacylglycerol-kinases are a family of related lipid kinases. There are currently 10 known isoforms of diacylglycerol kinases that are categorized into five groups based on similarities in their primary sequence. All of these enzymes catalyze the transfer of the gamma-phosphate of ATP to one lipid second messenger, diacylglycerol, thereby generating another lipid second messenger, phosphatidic acid. As a result, they are uniquely poised to regulate the relative levels of these two key second messengers. These enzymes show considerable diversity in their cellular and sub-cellular distribution which suggests a great diversity in physiological functions. One sub-cellular compartment that is receiving a considerable attention is the nucleus. A number of DGKs have been found to reside in, or translocate to the nucleus in response to agonists. In this review we focus primarily on the nuclear localization, modulation of intrinsic enzymatic activity, and the potential physiological roles of the six diacylglycerol kinases that have been found in the nucleus: DGK-alpha, DGK-gamma, DGK-delta, DGK-zeta, DGK-iota, and DGK-theta.