Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population
Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population
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DOI：
10.1097/wnr.0b013e328133265b
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发表时间：
2007-06-11
期刊：
影响因子：
1.7
通讯作者：
Toda, Tatsushi
中科院分区：
文献类型：
--
作者：
Satake, Wataru;Mizuta, Ikuko;Toda, Tatsushi
家系不平衡检验发现成纤维细胞生长因子20(FGF20)基因与帕金森病之间存在遗传关联。然而，这种关联并没有被病例对照关联研究复制。为了阐明FGF20基因与帕金森氏病之间的关联，我们试图通过使用大量日本样本(1388名患者和1891名对照)的病例对照关联研究来复制这种关联。Rs1721100等位基因C与G的差异有统计学意义(P=0.0089)，CC+CG与GG的差异有统计学意义(P=0.0053)。单倍型关联分析显示，单倍型2是帕金森病的保护性单倍型(排列-P=0.0075)。这些结果表明，FGF20基因是日本人群中帕金森病的易感基因。
A genetic association between the fibroblast growth factor 20 (FGF20) gene and Parkinson's disease has been found by the pedigree disequilibrium test. This association, however, was not replicated by a case-control association study. In order to clarify the association between the FGF20 gene and Parkinson's disease, we attempted to replicate this association by a case-control association study using a large number of Japanese samples (1388 patients and 1891 controls). rs1721100 exhibited a significant difference in allele C versus G (P=0.0089), and in genotype CC + CG versus GG (P=0.0053). Haplotype association analysis showed that haplotype 2 was the protective haplotype for Parkinson's disease (permutation-P=0.0075). These results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population.