Pannexin 1 as a driver of inflammation and ischemia-reperfusion injury.
Pannexin 1 as a driver of inflammation and ischemia-reperfusion injury.
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DOI：
10.1007/s11302-021-09804-8
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发表时间：
2021-12
影响因子：
3.5
通讯作者：
Isakson BE
中科院分区：
文献类型：
--
作者：
Koval M;Cwiek A;Carr T;Good ME;Lohman AW;Isakson BE
Pannexin 1（Panx 1）是一种广泛表达的蛋白质，形成大电导通道，其在许多不同的炎症和损伤反应中起重要作用。越来越多的证据表明，从Panx 1通道释放的ATP以及代谢物提供了有效的旁分泌和自分泌信号分子，可以调节损伤反应的不同成分。作为具有广泛选择透过性的通道，Panx 1通道介导从钙到细菌衍生分子的多种溶质的分泌和摄取。在这篇综述中，我们描述了Panx1如何响应不同的促炎刺激，主要集中在血管系统协调的信号。还讨论了Panx1如何介导受损细胞释放ATP。Panx1作为许多不同生理反应的核心成分的能力已被证明是严重依赖于表达的背景，翻译后修饰，相互作用的合作伙伴，和刺激的模式。
Pannexin 1 (Panx1) is a ubiquitously expressed protein forming large conductance channels that are central to many distinct inflammation and injury responses. There is accumulating evidence showing ATP released from Panx1 channels, as well as metabolites, provide effective paracrine and autocrine signaling molecules that regulate different elements of the injury response. As channels with a broad range of permselectivity, Panx1 channels mediate the secretion and uptake of multiple solutes, ranging from calcium to bacterial derived molecules. In this review, we describe how Panx1 functions in response to different pro-inflammatory stimuli, focusing mainly on signaling coordinated by the vasculature. How Panx1 mediates ATP release by injured cells is also discussed. The ability of Panx1 to serve as a central component of many diverse physiologic responses has proven to be critically dependent on the context of expression, post-translational modification, interacting partners, and the mode of stimulation.
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