Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway.
Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway.
复制标题
构巢曲霉中的降茄酸通过 Fas 介导的途径抑制人乳腺癌 MCF-7 细胞的增殖。
DOI：
10.1111/j.1742-7843.2008.00237.x
复制
发表时间：
2008
影响因子：
3.1
通讯作者：
Hsu,Ya-Ling
中科院分区：
文献类型：
--
作者：
Wang,ClayCC;Chiang,Yi-Ming;Kuo,Po-Lin;Chang,Jiunn-Kae;Hsu,Ya-Ling
研究了从构巢曲霉中分离的去甲异甘草酸在人乳腺癌MCF-7细胞中的抗增殖活性。为了进一步明确去甲甲异喹啉酸的抗癌机制，我们检测了其对细胞凋亡、细胞周期分布以及p53、p21/WAF 1、Fas/APO-1受体和Fas配体水平的影响。结果显示，去甲异烟酸诱导MCF-7细胞凋亡，而不介导p53和p21/WAF 1。我们认为Fas/Fas配体凋亡系统是去甲肌苷酸介导MCF-7细胞凋亡的主要途径。我们的研究首次报道了Fas/Fas配体凋亡系统的活性可能参与了去甲肌苷酸在MCF-7细胞中的抗增殖活性。
Norsolorinic acid, isolated from theAspergillus nidulans, was investigated for its antiproliferative activity in human breast adenocarcinoma MCF‐7 cells. To identity the anticancer mechanism of norsolorinic acid, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO‐1 receptor and Fas ligand. The results showed that norsolorinic acid induced apoptosis of MCF‐7 cells without mediation of p53 and p21/WAF1. We suggest that Fas/Fas ligand apoptotic system is the main pathway of norsolorinic acid‐mediated apoptosis of MCF‐7 cells. Our study reports here for the first time that the activity of the Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of norsolorinic acid in MCF‐7 cells.