Probiotics and the gut microbiota in intestinal health and disease.
Probiotics and the gut microbiota in intestinal health and disease.
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DOI：
10.1038/nrgastro.2010.117
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
Walker WA
中科院分区：
文献类型：
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作者：
Gareau MG;Sherman PM;Walker WA
益生菌的使用越来越受欢迎，用于预防和治疗各种疾病。虽然越来越多的进行良好的，前瞻性的，随机的，对照的临床试验正在出现，并正在进行潜在的作用机制的调查，问题仍然是关于益生菌在健康和疾病中的特定免疫和生理作用。本文综述了益生菌治疗成人和儿童肠道疾病的临床试验的最新进展。最近在体外和体内的研究有关的各种益生菌制剂的潜在作用机制的概述也被考虑。
The use of probiotics is increasing in popularity for both the prevention and treatment of a variety of diseases. While a growing number of well-conducted, prospective, randomized, controlled, clinical trials are emerging and investigations of underlying mechanisms of action are being undertaken, questions remain with respect to the specific immune and physiological effects of probiotics in health and disease. This Review considers recent advances in clinical trials of probiotics for intestinal disorders in both adult and pediatric populations. An overview of recent in vitro and in vivo research related to potential mechanisms of action of various probiotic formulations is also considered.